Microbial Markers for AGI

• Conditions: Acute Gastrointestinal Injury
• Interventions: Other: none intervention

• Registration Number: NCT04957888
• Lead Sponsor: Peking University Third Hospital

Brief Summary

AGI is very common in ICU and sometimes will trigger the development of gut derived sepsis. Thus, to find out the biomarker in early stage is very important to improve the overall prognosis of critically ill patients. In this project we try to find out the microbial biomarker of AGI through multi-omic technology.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-07-01
• Primary Completion: 2021-06-01
• Study First Submitted: 2021-06-29
• Status Verified: 2021-07
• Study Completion: 2021-07-01
• Study First Submitted QC: 2021-07-07
• Last Update Submitted: 2021-07-07
• Study First Posted: 2021-07-12
• Last Update Posted: 2021-07-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 584

Inclusion Criteria

All those critically ill patients with anticipated ICU stay for more than 2 days

Read More

Exclusion Criteria

Patients will be excluded if they have any of the following situations: patients who have not signed the informed consent; Unable to tolerate intra-abdominal pressure monitoring; pregnant woman; Patients after bladder surgery; Systemic diseases and recent use of related drugs; He had a history of infectious diseases, such as tuberculosis or PPD positive. History of hypertension and poor blood pressure control (SBP / DBP > = 140mmHg); Patients with severe mental illness; Long term use of traditional Chinese medicine, probiotics, gastric mucosal protective agents, proton pump inhibitors, chemotherapy or immunosuppressive drugs, etc. were not included if the drug was not stopped within one month before admission.

Read More

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
training group	none intervention	the observational group to find out the potential biomarker
validation group	none intervention	the validation group to validate the parameters used for early diagnosis

Primary Outcome Measures

Name	Time	Method
The AUC value of the combined markers	1 year	The combined diagnostic accuracy of AGI through omic parameters

Trial Locations

Locations (1)

Peking University Third Hospital; 🇨🇳 Beijing, Beijing, China