NCT04957888Unknown不适用
Investigation on the Microbial Biomarkers of AGI in the Early Stage
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 584
- 试验地点
- 1
- 主要终点
- The AUC value of the combined markers
研究概览
简要总结
AGI is very common in ICU and sometimes will trigger the development of gut derived sepsis. Thus, to find out the biomarker in early stage is very important to improve the overall prognosis of critically ill patients. In this project we try to find out the microbial biomarker of AGI through multi-omic technology.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All those critically ill patients with anticipated ICU stay for more than 2 days
排除标准
- •Patients will be excluded if they have any of the following situations: patients who have not signed the informed consent; Unable to tolerate intra-abdominal pressure monitoring; pregnant woman; Patients after bladder surgery; Systemic diseases and recent use of related drugs; He had a history of infectious diseases, such as tuberculosis or PPD positive. History of hypertension and poor blood pressure control (SBP / DBP > = 140mmHg); Patients with severe mental illness; Long term use of traditional Chinese medicine, probiotics, gastric mucosal protective agents, proton pump inhibitors, chemotherapy or immunosuppressive drugs, etc. were not included if the drug was not stopped within one month before admission.
结局指标
主要结局
The AUC value of the combined markers
时间窗: 1 year
The combined diagnostic accuracy of AGI through omic parameters
次要结局
未报告次要终点
研究者
研究点 (1)
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