MRI and Decline of Aging Aviator Performance
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 67
- 试验地点
- 1
- 主要终点
- flight simulator performance summary score
研究概览
简要总结
The primary purpose of this study is to apply state-of-the-art Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopic Imaging (MRSI) techniques to measure changes over time in the brain.
详细描述
We expect that MRI and MRSI techniques will be a useful adjunct in research efforts to understand individual differences in performance of a complex attention-demanding task, such as flying a plane or driving a car. Other predictors of change in performance of a complex task may include simple tests of processing speed and working memory, past training and recent practice of the task, and genetic risk factors for degenerative brain disease. In this project, we will examine whether baseline MR measures are as useful as longitudinal MR measures in predicting amount of change over time in task performance.
This research is part of a long-term effort to achieve earlier identification of individuals at risk of decline and ultimately minimize loss of function.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 45 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects will be included if they have participated in the protocol "Age-Related Longitudinal Changes in Aviator Performance" and agree to participate in this protocol.
排除标准
- •Subjects will be excluded if they currently have a major neurological disease, unstable/untreated medical disease (such as untreated hypertension).
- •In consideration of the magnetic fields in which subjects will be placed for the MR scanning, we will also exclude subjects who are unable to safely and comfortably complete the scanning session. This includes individuals who are wearing any metal prosthesis or who have cardiac pacemakers or any other nonremovable metal objects.
- •Subjects reporting a history of severe claustrophobia or poorly controlled back pain will be excluded because it is unlikely they could comfortably remain still in the MRI scanner for the duration of the scan.
- •In addition, subjects who do not fit in the apparatus will also be excluded.
结局指标
主要结局
flight simulator performance summary score
时间窗: yearly for up to 6 years
z-score composite of executing ATC communications, avoiding traffic, monitoring engine malfunctions, visual approach and landing
次要结局
- CogScreen-AE(yearly)
- Salthouse processing speed measures(yearl)
研究者
Joy Taylor
Clinical Professor (affiliated), Psychiatry & Behavioral Sciences
Stanford University