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Clinical Trials/NL-OMON56592
NL-OMON56592
Recruiting
Not Applicable

Biomarker-Guided Intervention to Prevent Acute Kidney Injury after Major Surgery; The Prospective Multicenter Randomized Controlled Interventional Trial - BigpAK-2

niversity Hospital Muenster, Dept. of Anesthesiology, Intensive Care Medicine and Pain Therapy0 sites30 target enrollmentTBD
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ConditionsAKI (Acute Kidney Injury)Renal Insufficiency10038430

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
AKI (Acute Kidney Injury)
Sponsor
niversity Hospital Muenster, Dept. of Anesthesiology, Intensive Care Medicine and Pain Therapy
Enrollment
30
Status
Recruiting
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
last year
Study Type
Interventional

Investigators

Sponsor
niversity Hospital Muenster, Dept. of Anesthesiology, Intensive Care Medicine and Pain Therapy

Eligibility Criteria

Inclusion Criteria

  • •1\. Patients after major surgery who need to be admitted to the ICU
  • •2\. Age \> 18 years
  • •3\. \[TIMP\-2]\*\[IGFBP7] \>\= 0\.3 4\-18 hours after surgery
  • •4\. Inserted jugular central venous line and a urinary catheter
  • •5\. Written informed consent
  • •6\. At least one additional risk factor for AKI:
  • •a. Age \> 75 years
  • •b. Critical illness such as ongoing requirement of vasopressors or mechanical
  • •ventilation postoperatively
  • •c. Pre\- existing chronic kidney disease (eGFR\< 60 ml/ min)

Exclusion Criteria

  • •1\. Pregnancy or breastfeeding
  • •2\. Pre\- existing high stages of chronic kidney disease (\>\=stage 4 i.e. eGFR \< 30
  • •3\. Kidney transplant within the last 12 months
  • •4\. Known (Glomerulo\-) Nephritis, interstitial nephritis or vasculitis
  • •5\. Anuria at inclusion time
  • •6\. Preexisting AKI
  • •7\. Renal replacement therapy within the last 90 days
  • •8\. Indication for renal replacement at the time of inclusion
  • •9\. Participation in another interventional trial that investigates a
  • •drug/intervention that affects

Outcomes

Primary Outcomes

Not specified

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