Screening for transient leukemia in children with Down syndrome.
Recruiting
- Conditions
- Transient myeloproliferative disorder in children with Down syndrome.
- Registration Number
- NL-OMON19924
- Brief Summary
Blink M, Buitenkamp TD, van Wouwe JP, van Wering ER, van der Velden VHJ, Zwaan CM. Ontwikkelingen in de diagnostiek en behandeling van leukemie bij kinderen met Down syndroom. Tijdschrift voor Kindergeneeskunde. Accepted for publication.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 811
Inclusion Criteria
1. All children with Down syndrome;
2. Age < 4 weeks;
Exclusion Criteria
1. Children in whom the diagnosis Down syndrome can not be confirmed;
2. Complications that make sampling unwanted or impossible.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. To determine the population-based frequency of TMD;<br /><br>2. To establish and investigate the relation of TMD and ML-DS;<br /><br>3. To see if treatment of TMD can prevent TMD-associated mortality and the development of ML-DS in later life.<br>
- Secondary Outcome Measures
Name Time Method 1. To detect new genetic factors related to the progression of TMD to ML-DS;<br /><br>2. To investigate the presence of lymphoid pre-leukemic clones in neonatal blood samples of TMD;<br /><br>3. To describe the hematological abnormalities and clinical characteristics in patients with and without TMD.