To Develop and Validate a Nasoendoscopic Intelligent Diagnostic System for Nasopharyngeal Carcinoma
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Otolaryngological Disease
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
- Enrollment
- 1000
- Locations
- 3
- Primary Endpoint
- Pathological diagnosis
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Nasopharyngeal carcinoma (NPC) occurs at a high frequency in southern China, northern Africa, and Alaska, with a reported incidence of 30 cases per 100 000 in Guangdong Province. Endoscopic examination and biopsy are the main methods used for detection and diagnosis of NPC. Early NPC patients achieve favourable prognoses after concurrent radiotherapy and chemotherapy in compassion with advanced NPC patients.
Here, the investigators focused on the utility of artificial intelligence to detect early NPC, which based on white light imaging (WLI) and Narrow-band imaging (NBI) nasoendoscopic examination. Having access to this unique population provides an unprecedented opportunity to investigate the effect of intelligent system on diverse nasopharyngeal lesions detection and develop a novel Computer-Aided Diagnosis System.
Investigators
Weiping Wen
Vice President of First Affiliated Hospital, Sun Yat-Sen University; President of sixth Affiliated Hospital, Sun Yat-Sen University
First Affiliated Hospital, Sun Yat-Sen University
Eligibility Criteria
Inclusion Criteria
- •Older than 18 years of age
Exclusion Criteria
- •Refuse to sign the informed consent statement
- •Patients who have contraindications, e.g. coagulation dysfunction, drug allergy.
Outcomes
Primary Outcomes
Pathological diagnosis
Time Frame: baseline
All lesions, detected by either WLI or NBI, are biopsied. 2 experienced pathologists, who were blinded to the endoscopic and intelligent assessment, evaluate the pathological nature of the biopsied lesion independently, and 2 professors with over 10 years of experience in Otolaryngology and pathology department are consulted in cases of disagreement.
Secondary Outcomes
- Lesion range(baseline)