Study of Auditory Perception After Progressive Exposure to Aversive Sounds in People With Misophonia

Not Applicable

Not yet recruiting

• Conditions: Misophonia

• Registration Number: NCT06921187
• Lead Sponsor: Institut Pasteur

Brief Summary

The primary objective of the project is to characterise and measure the auditory perception of subjects with misophonia compared with the auditory perception of control subjects.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-03
• Study First Submitted: 2025-03-18
• Study First Submitted QC: 2025-04-03
• Last Update Submitted: 2025-04-03
• Study First Posted: 2025-04-10
• Last Update Posted: 2025-04-10
• Study Start: 2025-06
• Primary Completion: 2026-03
• Study Completion: 2026-03

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 110

Inclusion Criteria

For all participants

• Obtain oral consent from the participant after receiving information about the study,
• Be 18 years or older on the day of inclusion,
• Be fluent in French (spoken and written),
• Have no known hearing loss, verified by pure tone audiometry.
• Declare that they do not have tinnitus,
• Declare that they do not have hyperacusis, verified by measuring discomfort thresholds.
• Be affiliated to the social security or equivalent scheme.

For participants with misophonia:

• Declare discomfort, reduced tolerance to specific sounds (mouth noises, throat clearing, breathing, etc.).

Exclusion Criteria

• Bear the after-effects of an ear infection and/or have a history of an ENT disease that permanently affects hearing or balance (vestibular schwannoma, Ménière's disease, sudden or fluctuating deafness, congenital hypoacusis),
• Be under guardianship,
• deprived of liberty by judicial or administrative decision, or subject to legal protection.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
score on a visual analogue scale from 0 (pleasant sound) to 10 (unpleasant sound)	1 week after enrollment	sounds will be presented at different decibels and the subject will be asked to rate the pleasantness/unpleasantness of the sound on a visual analogue scale
score on a visual analogue scale from 0 (very low intensity) to 10 (extremely intense)	1 week after enrollment	sounds will be presented at different decibels and the subject will be asked to rate the intensity of the sound on a visual analogue scale

Secondary Outcome Measures

Name	Time	Method
Measuring the consistency of the psychoacoustic test	1 week after enrollement	consistency measured by calculating Cronbach's alpha coefficient
the number of redundant themes in the semi-structured interviews	1 month after enrollment	the interviews consist of open-ended questions covering different aspects of the experiences of misophone subjects
score on a visual analogue scale from 0 (very little discomfort) to 10 (extreme discomfort)	1 month after enrollment and 2 months after enrollment

Trial Locations

Locations (2)

Centre de Recherche en Psychologie et Neuroscience (CRPN); 🇫🇷 Marseille, France

CEntre de Recherche et d'Innovation en Audiologie Humaine; 🇫🇷 Paris, France