The effect of antioxidant MitoQ10 on PCOS
Phase 2
Recruiting
- Conditions
- polycyctic ovarian syndrome.Polycystic ovarian syndrome
- Registration Number
- IRCT20171210037804N1
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 36
Inclusion Criteria
Patients with polycystic ovarian syndrome which its diagnosis is based on the Rotterdam ESHRE/ASRM criteria (Rotterdam ESHRE/ASRMcriteria 2004) are included in this study.
Exclusion Criteria
basal FSH >10 IU/L;
treatment with estrogen–progestin and/or other hormonal therapies in the six months before the study;
in the presence of ovarian cysts with a diameter gre14 mm observed in two ultrasound examinations conducted within thirty days of each other;
endometriosis; genetic and/or autoimmune aberrations; chronic liver disease; chronic systemic inflammatory diseases; hyper- and hypo-adrenal cortical diseases;
type 2 diabetes mellitus;
intolerance to carbohydrates;
presence of a single ovary; and
previous ovarian surgery.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method TRX gene and protein expression. Timepoint: After 6 weeks intervention. Method of measurement: Western Blot, RT-PCR.;TXNIP gene and protein expression. Timepoint: After 6 weeks intervention. Method of measurement: Western Blot, RT-PCR.;ASK1 gene and protein expression. Timepoint: After 6 weeks intervention. Method of measurement: Western Blot, RT-PCR.;Oocyte number. Timepoint: After 6 weeks intervention. Method of measurement: microscope.;Embryo number. Timepoint: After 6 weeks intervention. Method of measurement: microscope.;Embryo quality. Timepoint: After 6 weeks intervention. Method of measurement: microscope.;Oocyte quality. Timepoint: After 6 weeks intervention. Method of measurement: microscope.
- Secondary Outcome Measures
Name Time Method Pregnancy rate. Timepoint: after intervention. Method of measurement: B-HCG Test.