Systematic glaucoma screening and diagnostic effectiveness: can early detection improve patient outcomes?
Not Applicable
Completed
- Conditions
- GlaucomaEye - Diseases / disorders of the eyePublic Health - Health promotion/educationPublic Health - Health service research
- Registration Number
- ACTRN12615000307505
- Lead Sponsor
- Prof Michael Kalloniatis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 361
Inclusion Criteria
18-80 year, gonioscopically open angles, IOP below 32 in either eye, normal optic disc at initial clinical examination and on stereoscopic photographs as determined by the two independent ophthalmologists with specialty in glaucoma, 2 normal and reliable visual field tests per eye at initial examination as determined by the two independent ophthalmologists with specialty in glaucoma.
Exclusion Criteria
Glaucoma other than primary open angle glaucoma, previous intraocular surgery (other than uncomplicated cataract extraction with posterior chamber lens implantation), and any disases capable of causing visual field loss or optic disc deterioration.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Diagnostic accuracy measured as the proportion of true positive referrals defined as those patients referred as glaucoma suspects or with suggested glaucomatous changes that are confirmed during examination.[five years]
- Secondary Outcome Measures
Name Time Method Predictors for earlier diagnosis defined as exam outcomes that show a better correlation with the determined patient glaucoma status than the primary outcome. Multivariate regression models will be applied to identify those exam outcomes that result in the best prediction of the patient disease status at the study end point.[5 years]