TIARA (repetitive Transcranial magnetic stimulation and neuroImaging in AnoRexia nervosA): a sham-controlled randomised feasibility study of repetitive transcranial magnetic stimulation (rTMS) as an adjunct to treatment as usual (TAU) in adults with severe and enduring anorexia nervosa (SE-AN)

King's College London0 个研究点目标入组 34 人开始时间: 2015年7月23日最近更新: 2023年8月28日

适应症

试验速览

2015 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/26634828 protocol 2018 Results article in https://www.ncbi.nlm.nih.gov/pubmed/30012789 results (added 23/10/2019) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/34243816/ (added 12/07/2021) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35150473/ Participant experiences (added 14/02/2022) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33509288/ (added 18/08/2023)

•1. Male and female participants who are aged 18 or over
•2. BMI between 14 and 18.5 kg/m2
•3. Right-handed
•4. Current DSM-V diagnosis of AN-Restricting type (AN-R) or AN-Binge/purging type (AN-BP) and an illness duration of 3 years or more
•5. Must have completed at least one adequate previous course of eating disorder treatment (e.g. one 6-month course of specialist outpatient therapy, specialist day-care or in-patient treatment for refeeding)
•6. Must have approval from treating Eating Disorders clinician or GP to participate

•1. Having a history of head or eye injury
•2. Having a history of a neurological disease including previous seizures of any kind
•3. Having metallic implants anywhere in the head or body
•4. Being on a dose of any psychotropic medication that has not been stable for at least 14 days prior to participation in the study
•5. Taking antipsychotic medication
•6. Taking anti-convulsive medication
•7. Being pregnant
•8. Having a current other major psychiatric disorder (e.g., major depressive disorder, substance dependence, schizophrenia or bipolar disorder) needing treatment in its own right
•9. Excessive alcohol (> 3 units per day, 5 days of the week) and/or cigarette consumption (> 15 cigarettes per day)
•10. Severe abnormalities in their screening clinical blood sample
•11. An rTMS safety questionnaire and an MRI safety questionnaire will also be administered and if considered not safe to deliver rTMS or undergo MRI scanning, people will subsequently be excluded on this basis.

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