KCT0008806
Recruiting
N/A
Evaluation of association of vascular aging, chronic inflammation and degenerative brain disease
ConditionsMental and behavioural disorders
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Mental and behavioural disorders
- Sponsor
- Gachon University Gil Medical Center
- Enrollment
- 350
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\-Alzheimer's Disease (AD): Participants with a Clinical Dementia Rating (CDR) of 0\.5 or higher and who meet the DSM\-IV\-TR criteria for dementia and the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS\-ADRDA) criteria for probable or possible AD.
- •\-Subcortical Vascular Dementia (SVaD): Participants with a CDR of 0\.5 or higher, who meet the DSM\-IV criteria for vascular dementia, and show moderate or higher white matter changes on MRI FLAIR imaging based on the modified Fazeka's scale.
- •Mild Cognitive Impairment (MCI)
- •: Participants with a Clinical Dementia Rating (CDR) of 0\.5, but without dementia according to the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text\-revision (DSM\-IV\-TR) criteria.
- •Cognitively Normal
- •: Participants with a Clinical Dementia Rating (CDR) of 0 and without objective evidence of cognitive decline (less than \-1\.5 standard deviations) based on comprehensive neuropsychological test.
Exclusion Criteria
- •\-Pregnant women (Excluded if even slightly suspected of being pregnant based on surveys or menstrual cycle information)
- •\-Women currently breastfeeding
- •\-Patients with severely compromised overall health to the extent that conducting tests is difficult
- •\-Individuals with seizure disorders such as claustrophobia or other major neurological conditions, such as traumatic brain injury, Parkinson's disease, \-Huntington's disease, motor neuron diseases, multiple sclerosis, etc.
- •(Note: Exclusion is only considered if the study director (physician) deems it would significantly affect the study.)
- •\-Patients diagnosed with psychiatric disorders such as schizophrenia
- •\-Patients with brain tumors, hydrocephalus, encephalitis, or metabolic encephalopathy
- •\-Women who are currently pregnant or using intrauterine contraceptive devices
- •\-Individuals deemed inappropriate for the study by the clinical researcher
- •\-Persons with cardiac pacemakers or metallic implants within the body
Outcomes
Primary Outcomes
Not specified
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