KCT0008806RecruitingUnknown
Evaluation of association of vascular aging, chronic inflammation and degenerative brain disease
Conditions
Trial Snapshot
- Phase
- Unknown
- Status
- Recruiting
- Enrollment
- 350
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 45(Year) to o Limit (—)
- Sex
- All
Inclusion Criteria
- •-Alzheimer's Disease (AD): Participants with a Clinical Dementia Rating (CDR) of 0.5 or higher and who meet the DSM-IV-TR criteria for dementia and the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria for probable or possible AD.
- •-Subcortical Vascular Dementia (SVaD): Participants with a CDR of 0.5 or higher, who meet the DSM-IV criteria for vascular dementia, and show moderate or higher white matter changes on MRI FLAIR imaging based on the modified Fazeka's scale.
- •Mild Cognitive Impairment (MCI)
- •: Participants with a Clinical Dementia Rating (CDR) of 0.5, but without dementia according to the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text-revision (DSM-IV-TR) criteria.
- •Cognitively Normal
- •: Participants with a Clinical Dementia Rating (CDR) of 0 and without objective evidence of cognitive decline (less than -1.5 standard deviations) based on comprehensive neuropsychological test.
Exclusion Criteria
- •-Pregnant women (Excluded if even slightly suspected of being pregnant based on surveys or menstrual cycle information)
- •-Women currently breastfeeding
- •-Patients with severely compromised overall health to the extent that conducting tests is difficult
- •-Individuals with seizure disorders such as claustrophobia or other major neurological conditions, such as traumatic brain injury, Parkinson's disease, -Huntington's disease, motor neuron diseases, multiple sclerosis, etc.
- •(Note: Exclusion is only considered if the study director (physician) deems it would significantly affect the study.)
- •-Patients diagnosed with psychiatric disorders such as schizophrenia
- •-Patients with brain tumors, hydrocephalus, encephalitis, or metabolic encephalopathy
- •-Women who are currently pregnant or using intrauterine contraceptive devices
- •-Individuals deemed inappropriate for the study by the clinical researcher
- •-Persons with cardiac pacemakers or metallic implants within the body
- •(Except for titanium and titanium alloy implants, or if a specialist confirms that there are no issues with a 3T MRI scan)
- •-Patients with metallic objects in the head and neck that can cause image distortion during MRI scans
- •-Individuals who have received radiation exposure exceeding 50msV (5rem) within the past year, including those who have undergone multiple scans such as PET, coronary angiography, abdomen-pelvic CT, etc.
- •-Individuals working in occupations with significant radiation exposure
Investigators
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