Evaluation of association of vascular aging, chronic inflammation and degenerative brain disease

Gachon University Gil Medical Center0 sites350 target enrollmentStarted: TBDLast updated: October 16, 2023

Conditions

Trial Snapshot

No summary available.

•-Alzheimer's Disease (AD): Participants with a Clinical Dementia Rating (CDR) of 0.5 or higher and who meet the DSM-IV-TR criteria for dementia and the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria for probable or possible AD.
•-Subcortical Vascular Dementia (SVaD): Participants with a CDR of 0.5 or higher, who meet the DSM-IV criteria for vascular dementia, and show moderate or higher white matter changes on MRI FLAIR imaging based on the modified Fazeka's scale.
•Mild Cognitive Impairment (MCI)
•: Participants with a Clinical Dementia Rating (CDR) of 0.5, but without dementia according to the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text-revision (DSM-IV-TR) criteria.
•Cognitively Normal
•: Participants with a Clinical Dementia Rating (CDR) of 0 and without objective evidence of cognitive decline (less than -1.5 standard deviations) based on comprehensive neuropsychological test.

•-Pregnant women (Excluded if even slightly suspected of being pregnant based on surveys or menstrual cycle information)
•-Women currently breastfeeding
•-Patients with severely compromised overall health to the extent that conducting tests is difficult
•-Individuals with seizure disorders such as claustrophobia or other major neurological conditions, such as traumatic brain injury, Parkinson's disease, -Huntington's disease, motor neuron diseases, multiple sclerosis, etc.
•(Note: Exclusion is only considered if the study director (physician) deems it would significantly affect the study.)
•-Patients diagnosed with psychiatric disorders such as schizophrenia
•-Patients with brain tumors, hydrocephalus, encephalitis, or metabolic encephalopathy
•-Women who are currently pregnant or using intrauterine contraceptive devices
•-Individuals deemed inappropriate for the study by the clinical researcher
•-Persons with cardiac pacemakers or metallic implants within the body
•(Except for titanium and titanium alloy implants, or if a specialist confirms that there are no issues with a 3T MRI scan)
•-Patients with metallic objects in the head and neck that can cause image distortion during MRI scans
•-Individuals who have received radiation exposure exceeding 50msV (5rem) within the past year, including those who have undergone multiple scans such as PET, coronary angiography, abdomen-pelvic CT, etc.
•-Individuals working in occupations with significant radiation exposure

Sponsor