Comparing the effectiveness of injectable pantoprazole, oral pantoprazole and injectable famotidine for stress ulcer prophylaxis in the intensive care unit.

Phase 2

Recruiting

• Conditions: gastric stress ulcer prophylaxes.; Peptic ulcer, site unspecified

• Registration Number: IRCT20200322046833N3
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 January 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patients over 18 years of age hospitalized in the intensive care unit who have a nasogastric tube and are indicated for the prevention of peptic ulcer.
Sign the informed consent

Exclusion Criteria

Bariatric surgery
Gastrectomy surgery
Active gastrointestinal ulcer or gastrointestinal bleeding
Stomach malignancy
Patients who have received PPI and H2 Blocker drugs in the last 5 days
Patients whose gastric acid base is above 5

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Frequency of occurrence of pH less than 5 during the study. Timepoint: On day 1,3,5 and 7 stomach pH of patients is determined by digital laboratory pH meter and paper pH meter (to avoid the optical error of litmus paper, it is confirmed by two people), 3 times a day. Method of measurement: about 10 cc of stomach contents are aspirated one hour after gavage and measured with digital laboratory pH meter and paper pH meter (to avoid the optical error of litmus paper, it is confirmed by two people).

Secondary Outcome Measures

Name	Time	Method
Average changes of CRP/Alb - lymphocyte to neutrophil ratio - platelet to lymphocyte ratio on the first day compared to the seventh day in the group of injectable famotidine and injectable pantoprazole and oral pantoprazole in patients admitted to the intensive care unit. The number of days hospitalized in the intensive care unit in the group of injectable famotidine and injectable pantoprazole and oral pantoprazole in patients hospitalized in intensive care units. Mortality in the group of injectable famotidine and parenteral pantoprazole and oral pantoprazole in patients admitted to the intensive care unit. Timepoint: The inflammatory index CRP/Alb is checked on day 0 and day 7. The time of discharge from the intensive care unit or the death of patients is recorded. Method of measurement: The inflammatory index CRP/Alb is checked on day 0 and day 7. The time of discharge from the intensive care unit or the death of patients is recorded.