Ultra-early Chest CT Improves Risk Prediction of Stroke-associated Pneumonia: Model Development and External Validation in a Multicentre Retrospective Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 1,499
- Locations
- 5
- Primary Endpoint
- Stroke-associated pneumonia
Study Overview
Brief Summary
Stroke-associated pneumonia (SAP) is a common and serious complication after acute ischaemic stroke (AIS). Existing scores rely mainly on clinical variables, and the added prognostic value of inflammatory markers and early chest CT findings remains uncertain. We developed and externally validated an early multimodal model combining clinical severity, inflammation, and chest CT abnormalities, and explored risk-stratified associations between prophylactic antibiotics and SAP.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patients aged ≥18 years;
- •Admitted to a participating stroke centre with neuroimaging-confirmed acute ischaemic stroke ;
- •Had chest CT performed within 24 hours of stroke onset.
Exclusion Criteria
- •Chest CT images unavailable or incomplete for assessment;
- •Insufficient clinical documentation to ascertain stroke-associated pneumonia occurrence within 7 days after stroke onset
Arms & Interventions
Development (Derivation) cohort
External validation cohort
Outcomes
Primary Outcomes
Stroke-associated pneumonia
Time Frame: within 7 days after stroke onset
SAP was defined as pneumonia occurring within 7 days after stroke onset. Potential events were screened using discharge diagnosis codes and medical record documentation, and then confirmed by manual chart review using prespecified clinical, laboratory, and radiological criteria consistent with the Pneumonia in Stroke Consensus Group and modified CDC definitions.
Secondary Outcomes
No secondary outcomes reported
Investigators
Ji Xunming,MD,PhD
Professor of Neurology, Xuanwu Hospital, Capital Medical University
Capital Medical University