DRKS00000788已完成2 期
Differential effect of Carbamazepine on cortical excitability in subjects with different genotypes for SCN1A as measured by transcranial magnetic stimulation (TMS) - EPICURE SP 5- TMS- SCN1A
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 101
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized controlled study
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 one（—）
- 性别
- All
入选标准
- •Men and women age =18 years
- •Righthandedness as investigated by the Edinburgh handedness inventory (EHI =80)
- •Provided signed written informed consent
- •Cognitive and physical ability to understand the experimental procedure, to take the antiepileptic medication and to be investigated by TMS
排除标准
- •Progressive neurological disorder
- •Admission for a psychiatric disorder within the last 6 months, attempted suicide, psychosis or other severe psychiatric disorder
- •Severe disease of the liver, kidneys or heart
- •acute intermittend porphyria
- •Severe endocrinological disorder
- •Disturbances of the sodium levels
- •Pregnancy or lactation period
- •Epileptic or non-epileptic seizures
- •Chronic alcohol- or drug- abuse within the last two years
- •Allergic reaction to the medication tested
- •Intake of antiepileptic drugs or other drugs influencing cortical excitability
- •Metal implantates in head-neck-area
- •Other abnormal laboratory results, medical history or clinical findings that might be of disadvantage for the subject or the study
- •Inclusion in another clinical or neurophysiological study at the time of investigation
研究者
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