A proof-of-concept study to evaluate 99mTechnetium radiolabeled Fucoidan as a diagnostic modality for thrombosis
- Conditions
- Deep vein thrombosis
- Registration Number
- NL-OMON26785
- Lead Sponsor
- one
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 12
Inclusion Criteria
Adult subjects of either gender, aged 50 years or older, with a compression ultra-sound demonstrated acute DVT, < 24 hours after treatment initiation
BMI between 18 and 35 kg/m2
Exclusion Criteria
Standard contra-indications to SPECT
Any medical condition or treatment that could interfere with the conduct of the study in the opinion of the investigator
Inability or unwilling to comply with protocol requirements, or deemed by the investigator to have a disorder that may compromise the ability to give informed consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The difference in uptake value of 99mTc-Fucoidan in the affected vein versus the corresponding vein in the unaffected leg of patients with an acute DVT
- Secondary Outcome Measures
Name Time Method To assess the effect of of Fucoidan on monocyte–endothelial and monocyte-platelet interaction in stimulated endothelium ex vivo