The Role of Ophthalmologic Tests and EEG Imaging in Alzheimer's Disease
- Conditions
- Mild Cognitive Impairment
- Interventions
- Diagnostic Test: observational
- Registration Number
- NCT04277767
- Brief Summary
Alzheimer's disease (AD) is a prevalent, long-term progressive degenerative disorder with great social impact. It is currently thought that, in addition to neurodegeneration, vascular changes also play a role in the pathophysiology of the disease. Meantime, EEG resting state has also demonstrated significant change in patients with AD in neuroscience research area. Thus, the combination of these sensitive biomarkers would lead to a potential new biomarker for detection of AD, which has higher specificity and sensitivity.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
- Clinical diagnosis of Alzheimer's Disease
- neurologic disorders
- psychiatric disorders
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Patients with mild to moderate AD observational observational mild cognitive impairment (MCI) observational observational Normal controls observational observational
- Primary Outcome Measures
Name Time Method OCT retinal and choroidal thickness 2 days retinal structural anatomy
Retinal Photography vascular caliber 2 days use Retinal Photography to detect vascular caliber
functional connection strength in the brain network 7 days record resting-state EEG, use graph theory to calculate the functional connection strength
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Zhongshan Ophthalmic Center
🇨🇳Guangzhou, Guangdong, China