The Combination of Ophthalmologic Tests and EEG Imaging as a New Biomarker for Alzheimer's Disease
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- OCT retinal and choroidal thickness
研究概览
简要总结
Alzheimer's disease (AD) is a prevalent, long-term progressive degenerative disorder with great social impact. It is currently thought that, in addition to neurodegeneration, vascular changes also play a role in the pathophysiology of the disease. Meantime, EEG resting state has also demonstrated significant change in patients with AD in neuroscience research area. Thus, the combination of these sensitive biomarkers would lead to a potential new biomarker for detection of AD, which has higher specificity and sensitivity.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of Alzheimer's Disease
排除标准
- •neurologic disorders
- •psychiatric disorders
结局指标
主要结局
OCT retinal and choroidal thickness
时间窗: 2 days
retinal structural anatomy
Retinal Photography vascular caliber
时间窗: 2 days
use Retinal Photography to detect vascular caliber
functional connection strength in the brain network
时间窗: 7 days
record resting-state EEG, use graph theory to calculate the functional connection strength
次要结局
未报告次要终点
研究者
Jin Yuan
assistant dean
Zhongshan Ophthalmic Center, Sun Yat-sen University