Strategies for Assessment of Fluid Overload in Acute Decompensated Heart Failure

Terminated

• Conditions: Decompensated Heart Failure; Heart Failure
• Interventions: Other: Lung ultrasound; Other: Echocardiography; Other: Peripheral venous pressure; Other: Magnetic resonance imaging; Other: Pulmonary scintigraphy

• Registration Number: NCT04901039
• Lead Sponsor: Region Skane

Brief Summary

Heart failure (HF) is the endstage of all heart disease, characterized by inability of either the left or right heart or both to maintain sufficient output of blood for the demands of the body at normal filling pressures. Patients with HF are often admitted to hospital with decompensation and treated with diuretics. Residual congestion at discharge is associated with increased risk of early rehospitalization and adverse outcomes. However, determination of residual decompensation is complicated and a large number of patients admitted with decompensated heart failure are likely discharged before optimal decongestion has been achieved. Lung ultrasound (LUS) is a promising method to determine residual decompensation with the evaluation of B-lines. In this study our primary aim is to evaluate if LUS together with echocardiographic evaluation of filling pressure according to the European Society of Cardiology (ESC) algorithm performs better than clinical assessment to determine fluid status and risk of early rehospitalization in patients hospitalized for AHF.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-05-20
• Study First Submitted QC: 2021-05-20
• Study First Posted: 2021-05-25
• Study Start: 2022-04-14
• Primary Completion: 2023-06-01
• Study Completion: 2023-06-01
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-05
• Last Update Posted: 2024-03-07

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

Not provided

Exclusion Criteria

• Acute coronary syndrome, cardiogenic chock

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Decompensated heart failure	Lung ultrasound	Previously diagnosed heart failure presenting with decompensation to the emergency department
Decompensated heart failure	Echocardiography	Previously diagnosed heart failure presenting with decompensation to the emergency department
Decompensated heart failure	Peripheral venous pressure	Previously diagnosed heart failure presenting with decompensation to the emergency department
Decompensated heart failure	Magnetic resonance imaging	Previously diagnosed heart failure presenting with decompensation to the emergency department
Decompensated heart failure	Pulmonary scintigraphy	Previously diagnosed heart failure presenting with decompensation to the emergency department

Primary Outcome Measures

Name	Time	Method
Rehospitalization/mortality	2021-2023	Rehospitalization or death within 30 days due to decompensated heart failure

Trial Locations

Locations (2)

Helsingborg General Hospital; 🇸🇪 Helsingborg, Sweden

Skåne University Hospital; 🇸🇪 Malmö, Sweden