A Phase Ⅰ Clinical Study of Mitoxantrone Hydrochloride Liposome Injection in Combination With Bortezomib and Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma
试验速览
- 阶段
- 1 期
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Treatment-emergent adverse events (TEAEs)
研究概览
简要总结
The purpose of this study is to evaluate the safety and efficacy of mitoxantrone hydrochloride liposome injection in combination with bortezomib and dexamethasone in patients with relapsed or refractory multiple myeloma.
详细描述
This is a multicenter, open-label, phase I study aimed to evaluate the safety and efficacy of mitoxantrone hydrochloride liposome injection in combination with bortezomib and dexamethasone in patients with relapsed or refractory multiple myeloma. In the study, 60 patients will be recruited into three dose groups. All patients will receive the treatment for the planned 8 cycles(28 days per cycle）until disease progression or unacceptable drug-related adverse events
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients fully understand and voluntarily participate in this study and sign informed consent;
- •Aged 18-75 years, without gender limitation;
- •Patients with relapsed or refractory multiple myeloma(confirmed by histologically or cytologically) who had received at least one prior line regular treatment;
- •Patients have at least one of the following conditions:（1）Serum M protein≥10g/L;（2）Urine M protein≥200 mg/24h; （3）Serum free light chain(sFLC): κ/λ FLC ratio is abnormal and affected FLC ≥100mg /L
- •Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2;
- •Laboratory tests meet the following conditions:
- •Absolute neutrophil count (ANC) ≥1.5x10^9/L (No G-CSF treatment within 1 week prior to the laboratory test);
- •Platelet count ≥ 75x10^9/L (No platelet transfusion within 1 week prior to the laboratory test);
- •Total bilirubin ≤1.5upper limit of normal (ULN);
- •Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 ULN;
- •Creatinine clearance(Ccr) ≥30mL/min.
- •Females of childbearing potential must have a negative serum beta human chorionic gonadotrophin (β-hCG) pregnancy test result prior to enrollment and must agree to use an effective contraception method for the duration of the study treatment and 7 months after the last dose of study therapy.
- •Males patients and their partners must agree to use an effective contraceptive method for the duration of the study treatment and 4 months after the last dose of study therapy.
排除标准
- •Patients with amyloidosis or central nervous system invasion or on dialysis treatment.
- •Life expectancy < 3 months.
- •History of allergy to mitoxantrone hydrochloride or liposomes；or previous treatment with adriamycin or other anthracyclines, with the total cumulative dose (doxorubicin equivalent) ≥350 mg/m^
- •History of allergy (except local injection reaction) or intolerance to bortezomib；or one of the following conditions occurred with prior bortezomib regimens: no treatment response (not reach MR)，disease progression within 6 months after the end of last dose.
- •History of contraindications or intolerance to dexamethasone.
- •Any anti-myeloma drug treatment or radiotherapy within 4 weeks prior to the first dose; or enrolled in any other clinical trials of anti-myeloma drug within 3 months prior to the first dose.
- •History of autologous hematopoietic stem cell transplantation within 6 months prior to screening.
- •History of allogeneic hematopoietic stem cell transplantation or solid organ transplantation.
- •Adverse events from the previous treatment have not resolved to ≤ Grade 1 (except for alopecia, hyperpigmentation).
- •Patients with persistent Grade≥2 peripheral neuropathy or Grade 1 peripheral neuropathy with pain.
- •Patients with impaired cardiac function or significant cardiac disease.
- •HBsAg/HBcAb positive with HBV-DNA titer higher than the lower limit of the test value of the research center, or HCV antibody positive with HCV-RNA titer higher than the lower limit of the test value of the research center,or human immunodeficiency virus (HIV) antibody positive.
- •Patients with obvious digestive system dysfunction, which may affect intake, transport and absorption of the study drug.
- •Active bacterial, fungal or viral infections that require systemic treatment within 1 week prior to the first dose
- •Patients underwent major surgery within 6 weeks prior to the first dose, or had a surgical schedule during the study period;
- •History of additional malignant tumor within 5 years, except for locally curable cancer that has been cured.
- •Other medical conditions that, in the judgment of the investigator, may affect the patient's participation in this study.
- •Pregnant or breastfeeding women;
- •Not suitable for this study as decided by the investigator due to other reasons.
研究组 & 干预措施
12 mg/m ^ 2 dose group (ArmA)
Patients with relapsed or refractory multiple myeloma will receive mitoxantrone hydrochloride liposome in combination with bortezomib and dexamethasone for 8 cycles (planned) (28 days per cycle). The dose of mitoxantrone hydrochloride liposome is 12 mg/m^2
干预措施: Mitoxantrone Hydrochloride Liposome injection (Drug)
12 mg/m ^ 2 dose group (ArmA)
Patients with relapsed or refractory multiple myeloma will receive mitoxantrone hydrochloride liposome in combination with bortezomib and dexamethasone for 8 cycles (planned) (28 days per cycle). The dose of mitoxantrone hydrochloride liposome is 12 mg/m^2
干预措施: Bortezomib for Injection (Drug)
12 mg/m ^ 2 dose group (ArmA)
Patients with relapsed or refractory multiple myeloma will receive mitoxantrone hydrochloride liposome in combination with bortezomib and dexamethasone for 8 cycles (planned) (28 days per cycle). The dose of mitoxantrone hydrochloride liposome is 12 mg/m^2
干预措施: Dexamethasone Acetate Tablets (Drug)
16 mg/m ^ 2 dose group (ArmB)
Patients with relapsed or refractory multiple myeloma will receive mitoxantrone hydrochloride liposome in combination with bortezomib and dexamethasone for 8 cycles (planned) (28 days per cycle). The dose of mitoxantrone hydrochloride liposome is 16 mg/m^2
干预措施: Mitoxantrone Hydrochloride Liposome injection (Drug)
16 mg/m ^ 2 dose group (ArmB)
Patients with relapsed or refractory multiple myeloma will receive mitoxantrone hydrochloride liposome in combination with bortezomib and dexamethasone for 8 cycles (planned) (28 days per cycle). The dose of mitoxantrone hydrochloride liposome is 16 mg/m^2
干预措施: Bortezomib for Injection (Drug)
16 mg/m ^ 2 dose group (ArmB)
Patients with relapsed or refractory multiple myeloma will receive mitoxantrone hydrochloride liposome in combination with bortezomib and dexamethasone for 8 cycles (planned) (28 days per cycle). The dose of mitoxantrone hydrochloride liposome is 16 mg/m^2
干预措施: Dexamethasone Acetate Tablets (Drug)
20 mg/m ^ 2 dose group (ArmC)
Patients with relapsed or refractory multiple myeloma will receive mitoxantrone hydrochloride liposome in combination with bortezomib and dexamethasone for 8 cycles (planned) (28 days per cycle). The dose of mitoxantrone hydrochloride liposome is 20 mg/m^2
干预措施: Mitoxantrone Hydrochloride Liposome injection (Drug)
20 mg/m ^ 2 dose group (ArmC)
Patients with relapsed or refractory multiple myeloma will receive mitoxantrone hydrochloride liposome in combination with bortezomib and dexamethasone for 8 cycles (planned) (28 days per cycle). The dose of mitoxantrone hydrochloride liposome is 20 mg/m^2
干预措施: Bortezomib for Injection (Drug)
20 mg/m ^ 2 dose group (ArmC)
Patients with relapsed or refractory multiple myeloma will receive mitoxantrone hydrochloride liposome in combination with bortezomib and dexamethasone for 8 cycles (planned) (28 days per cycle). The dose of mitoxantrone hydrochloride liposome is 20 mg/m^2
干预措施: Dexamethasone Acetate Tablets (Drug)
结局指标
主要结局
Treatment-emergent adverse events (TEAEs)
时间窗: From the initiation of the first dose to 28 days after the last dose
To indentify the incidence of TEAEs
次要结局
- Clinical Benefit Rate(CBR)(Throughout the study treatment(Up to 32 weeks))
- Objective response rate (ORR)(Throughout the study treatment(Up to 32 weeks))
- Disease control rate(DCR)(Throughout the study treatment(Up to 32 weeks))
- Duration of response (DoR)(Throughout the study completion.(An average of 12 months))
- Progression-free survival (PFS)(Throughout the study completion.(An average of 12 months))
- Overall survival (OS)(Throughout the study completion.(An average of 36 months))