Coronary Artery Dysfunction After Stent Implantation and Effect of Aggressive Lipid-lowering Therapy by Statins - Role of Rho-kinase

Not Applicable

• Conditions: Ischemic heart disease

• Registration Number: JPRN-UMIN000000888
• Lead Sponsor: Kyushu University Graduate School of Medical Sciences Department of Cardiovascular Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-11-15
• Study Completion: 2011-03-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

Not provided

Exclusion Criteria

1.Patient with unstable angina or acute myocardial infarction 2.History of angiographycally-proven vasospastic angina 3.Contraindication for statins or calcium channel blockers 4.Familial hypercholesterolemia, liver cirrhosis or renal failure on chronic dialysis 5.Contraindication for intracoronary acetylcholine during coronary angiography

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Coronary vasospasm after 3-month trial therapy

Secondary Outcome Measures

Name	Time	Method
1) Cardiovascular events (cardiac death, myocardial infarction, revascularization by PCI or CABG) 2) Severity of angina by Canadian Cardiovascular Society (CCS) classification 3) Biomarkers in peripheral and coronary sinus blood 4) Coronary stenosis and plaque phenotype by angiography or intravascular ultrasound (IVUS) 5) Stent re-endothelialization by angioscopy or optical coherence tomography (OCT)