EMPACT-MI: A Study to Test Whether Empagliflozin Can Lower the Risk of Heart Failure and Death in People Who Had a Heart Attack (Myocardial Infarction)

Phase 3

Completed

• Conditions: Myocardial Infarction
• Interventions: Drug: Empagliflozin; Drug: Placebo

• Registration Number: NCT04509674
• Lead Sponsor: Boehringer Ingelheim

Brief Summary

This is a study in adults who had a heart attack (myocardial infarction). The purpose of this study is to find out whether a medicine called empagliflozin helps to lower the chances of having to go to the hospital for heart failure and whether it lowers the chances of dying from cardiovascular disease.

People who are in hospital may join the study soon after being treated for their heart attack. Participants are put into 2 groups by chance. One group takes 1 empagliflozin tablet a day. The other group takes 1 placebo tablet a day. Placebo tablets look like empagliflozin tablets but do not contain any medicine. All participants continue their standard treatment. Empagliflozin belongs to a class of medicines known as SGLT-2 inhibitors. Empagliflozin is a medicine that helps people with type 2 diabetes to lower their blood sugar. Researchers think that empagliflozin might also help people after heart attack who are at risk for heart failure, whether or not they have diabetes.

Participants are in the study for about 1 to 2 years. During this time, there are about 4 visits inperson, 2 visits are done either by phone or by use of an mobile application. Results between the empagliflozin and placebo groups are compared. The doctors also regularly check the general health of the participants.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-08-10
• Study First Submitted QC: 2020-08-10
• Study First Posted: 2020-08-12
• Study Start: 2020-12-16
• Primary Completion: 2023-11-05
• Study Completion: 2023-11-05
• Results First Submitted: 2024-11-04
• Status Verified: 2024-12
• Results First Submitted QC: 2024-12-18
• Last Update Submitted: 2024-12-18
• Results First Posted: 2025-01-07
• Last Update Posted: 2025-01-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 6522

Inclusion Criteria

1. Of full age of consent (according to local legislation, at least ≥ 18 years) at screening.

2. Signed and dated written informed consent in accordance with ICH-GCP and local legislation prior to admission to the trial.

3. Male or female patients. Women of childbearing potential (WOCBP) must be ready and able to use highly effective methods of birth control per ICH M3 (R2) that result in a low failure rate of less than 1% per year when used consistently and correctly. A list of contraception methods meeting these criteria is provided in the patient information.

4. Diagnosis of spontaneous Acute Myocardial Infarction (AMI): ST-Elevation Myocardial Infarction (STEMI) or Non-ST Elevation Myocardial Infarction (NSTEMI) with randomisation to occur no later than 14 calendar days after hospital admission. For patients with an in-hospital Myocardial Infarction (MI) as qualifying event, randomization must still occur within 14 days of hospital admission.

5. High risk of HF, defined as EITHER

   1. Symptoms (e.g. dyspnea; decreased exercise tolerance; fatigue), or signs of congestion (e.g. pulmonary rales, crackles or crepitations; elevated jugular venous pressure; congestion on chest X-ray), that require treatment (e.g. augmentation or initiation of oral diuretic therapy; i.v. diuretic therapy; i.v. vasoactive agent; mechanical intervention etc.) at any time during the hospitalization.

      OR

   2. Newly developed Left Ventricular Ejection Fraction (LVEF) < 45% as measured by echocardiography, ventriculography, cardiac Computer Tomography (CT), Magnetic Resonance Imaging (MRI) or radionuclide imaging during index hospitalisation.

6. In addition at least one of the following risk factors:

   • Age > 65 years,
   • Newly developed LVEF < 35%,
   • Prior MI (before index MI) documented in medical records,
   • Estimated Glomerular Filtration Rate (eGFR) < 60 ml/min/1.73m2 (using Chronic Kidney Disease Epidemiology Collaboration Equation (CKD-EPI) formula based on creatinine from local lab at any time during index hospitalisation),
   • Atrial fibrillation (persistent or permanent ; if paroxysmal, only valid if associated with index MI),
   • Type 2 diabetes mellitus (prior or new diagnosis),
   • N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) >1,400 pg/mL for patients in sinus rhythm, >2,800 pg/mL if atrial fibrillation; Brain Natriuretic Peptide (BNP) >350 pg/mL for patients in sinus rhythm, >700 pg/mL if atrial fibrillation, measured at any time during hospitalisation,
   • Uric acid >7.5 mg/dL (>446 μmol/L), measured at any time during hospitalisation,
   • Pulmonary Artery Systolic Pressure [or right ventricular systolic pressure] >40 mmHg (non-invasive [usually obtained from clinically indicated post-MI echocardiography] or invasive, at any time during hospitalisation),
   • Patient not revascularized (and no planned revascularization) for the index MI (Includes e.g. patients where no angiography is performed, unsuccessful revascularization attempts, diffuse atherosclerosis not amenable for intervention; but does NOT include if revascularization was not performed due to nonobstructive coronary arteries),
   • 3-vessel coronary artery disease at time of index MI,
   • Diagnosis of peripheral artery disease (extracoronary vascular disease, e.g. lower extremity artery disease or carotid artery disease).

Exclusion Criteria

1. Diagnosis of chronic Heart Failure (HF) prior to index MI.
2. Systolic blood pressure < 90 mmHg at randomisation.
3. Cardiogenic shock or use of i.v. inotropes in last 24 hours before randomisation.
4. Coronary Artery Bypass Grafting planned at time of randomisation.
5. Current diagnosis of Takotsubo cardiomyopathy.
6. Any current severe (stenotic or regurgitant) valvular heart disease.
7. eGFR < 20 ml/min/1.73m2 (using CKD-EPI formula based on most recent creatinine from local lab during index hospitalisation) or on dialysis.
8. Type I diabetes mellitus. Further exclusion criteria apply.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Empagliflozin 10 mg	Empagliflozin	-
Placebo	Placebo	-

Primary Outcome Measures

Name	Time	Method
Composite of Time to First Heart Failure Hospitalisation or All-cause Mortality	From randomisation or first study drug administration (if randomisation occurred after first drug administration), until individual day of trial completion. Up to 1004 days.	The composite of time to first heart failure hospitalization or all-cause mortality is reported as the incidence rate of the first occurrence of hospitalization for heart failure (HHF) or death, whichever is earliest.; The incidence rate was calculated as: the number of patients with an event for hospitalization for heart failure or death by treatment group during time at risk divided by the total time patients were at risk in that treatment group multiplied by 100 (per 100 Pt-years, Pt as abbreviation of patient).

Secondary Outcome Measures

Name	Time	Method
Key Secondary Endpoint - Total Number of Hospitalisations for Heart Failure (HHF) or All-cause Mortality	From randomisation or first study drug administration (if randomisation occurred after first drug administration), until individual day of trial completion. Up to 1004 days.	The total number of hospitalisations for heart failure (HHF) or all-cause mortality is reported using the adjusted event rate.; The adjusted event rate is based on a negative binomial model adjusted for treatment and type-2 diabetes at baseline, geographical region, age at baseline, estimated glomerular filtration rate at baseline, left ventricular ejection fraction at baseline, persistent or permanent atrial fibrillation at baseline, prior myocardial infarction at baseline, peripheral artery disease at baseline and smoking at baseline as covariates. The log(observation time) was used as an offset variable.
Key Secondary Endpoint - Total Number of Non-elective Cardiovascular (CV) Hospitalisations or All-cause Mortality	From randomisation or first study drug administration (if randomisation occurred after first drug administration), until individual day of trial completion. Up to 1004 days.	The total number of non-elective cardiovascular (CV) hospitalisations or all-cause mortality is reported using the adjusted event rate.; The adjusted event rate is based on a negative binomial model adjusted for treatment and type-2 diabetes at baseline, geographical region, age at baseline, estimated glomerular filtration rate at baseline, left ventricular ejection fraction at baseline, persistent or permanent atrial fibrillation at baseline, prior myocardial infarction at baseline, peripheral artery disease at baseline and smoking at baseline as covariates. The log(observation time) was used as an offset variable.
Key Secondary Endpoint - Total Number of Non-elective All-cause Hospitalisations or All-cause Mortality	From randomisation or first study drug administration (if randomisation occurred after first drug administration), until individual day of trial completion. Up to 1004 days.	The total number of non-elective all-cause hospitalisations or all-cause mortality is reported using the adjusted event rate.; The adjusted event rate is based on a negative binomial model adjusted for treatment and type-2 diabetes at baseline, geographical region, age at baseline, estimated glomerular filtration rate at baseline, left ventricular ejection fraction at baseline, persistent or permanent atrial fibrillation at baseline, prior myocardial infarction at baseline, peripheral artery disease at baseline and smoking at baseline as covariates. The log(observation time) was used as an offset variable.
Key Secondary Endpoint - Total Number of Hospitalisations for Myocardial Infarction (MI) or All-cause Mortality	From randomisation or first study drug administration (if randomisation occurred after first drug administration), until individual day of trial completion. Up to 1004 days.	The total number of hospitalisations for myocardial infarction (MI) or all-cause mortality is reported using the adjusted event rate.; The adjusted event rate is based on a negative binomial model adjusted for factors for treatment and type-2 diabetes at baseline, geographical region, age at baseline, estimated glomerular filtration rate at baseline, left ventricular ejection fraction at baseline, persistent or permanent atrial fibrillation at baseline, prior myocardial infarction at baseline, peripheral artery disease at baseline and smoking at baseline as covariates. The log(observation time) was used as an offset variable.
Time to Cardiovascular (CV) Mortality	From randomisation or first study drug administration (if randomisation occurred after first drug administration), until individual day of trial completion. Up to 1004 days.	The time to cardiovascular (CV) mortality is reported as the incidence rate of cardiovascular (CV) mortality, including deaths of unknown cause.; The incidence rate was calculated as: the number of patients with a cardiovascular death event by treatment group during time at risk divided by the total time patients were at risk in that treatment group multiplied by 100 (per 100 Pt-years, Pt as abbreviation of patient).

Trial Locations

Locations (432)

Charlotte Heart Group Research Center; 🇺🇸 Port Charlotte, Florida, United States

Royal Brisbane and Women's Hospital; 🇦🇺 Herston, Queensland, Australia

Penn Presbyterian Medical Center; 🇺🇸 Philadelphia, Pennsylvania, United States

One Heart Care Ventures; 🇨🇦 Mississauga, Ontario, Canada

Prairie Vascular Research Inc.; 🇨🇦 Regina, Saskatchewan, Canada

University of California Los Angeles; 🇺🇸 Los Angeles, California, United States

Grady Memorial Hospital; 🇺🇸 Atlanta, Georgia, United States

Women's College Hospital; 🇨🇦 Toronto, Ontario, Canada

Medisch Spectrum Twente; 🇳🇱 Enschede, Netherlands

Madras Medical Mission,; 🇮🇳 Chennai, India

GB Pant Institute of Post Graduate Medical Education and Research; 🇮🇳 New Delhi, India

Clincal Reabilitation Hospital, Cluj Napoca; 🇷🇴 Cluj Napoca, Romania

Country Clinical Emergency Hospital, Targu-Mures; 🇷🇴 Targu-Mures, Romania

Kiev City Clinical Hospital No. 5; 🇺🇦 Kiev, Ukraine

Regional Clinical Hospital, Ternopil; 🇺🇦 Ternopil, Ukraine

Kaiser Permanente; 🇺🇸 San Diego, California, United States

San Diego Cardiac Center; 🇺🇸 San Diego, California, United States

Sal Med Srl; 🇷🇴 Pitesti, Romania

Ibaraki Prefectural Central Hospital; 🇯🇵 Ibaraki, Kasama, Japan

The Heart House; 🇺🇸 Vineland, New Jersey, United States

SJH Cardiology Associates; 🇺🇸 Liverpool, New York, United States

Advanced Cardiovascular LLC; 🇺🇸 Alexander City, Alabama, United States

Hainan General Hospital; 🇨🇳 Haikou, China

Heart Center Research, LLC; 🇺🇸 Huntsville, Alabama, United States

Aultman Hospital; 🇺🇸 Canton, Ohio, United States

North Carolina Heart and Vascular; 🇺🇸 Raleigh, North Carolina, United States

Centro Medico Luquez; 🇦🇷 Cordoba, Argentina

Guthrie Medical Group PC; 🇺🇸 Sayre, Pennsylvania, United States

Trinity Health Center Medical Arts; 🇺🇸 Minot, North Dakota, United States

Texas Health Presbyterian Hospital Allen; 🇺🇸 Allen, Texas, United States

Upstate Cardiology, PA; 🇺🇸 Greenville, South Carolina, United States

Parkway Cardiology Associates; 🇺🇸 Oak Ridge, Tennessee, United States

Medication Management, LLC; 🇺🇸 Greensboro, North Carolina, United States

Kettering Medical Center; 🇺🇸 Kettering, Ohio, United States

Dallas VA Medical Center; 🇺🇸 Dallas, Texas, United States

Riverside Regional Medical Center; 🇺🇸 Newport News, Virginia, United States

Carient Heart and Vascular; 🇺🇸 Manassas, Virginia, United States

Cincinnati VA Medical Center; 🇺🇸 Cincinnati, Ohio, United States

Sanatorio Allende; 🇦🇷 Cordoba, Argentina

Pharmatex Research; 🇺🇸 Amarillo, Texas, United States

Sanatorio Modelo de Quilmes; 🇦🇷 Quilmes, Argentina

Corporacion Medica de Gral. San Martin S.A.; 🇦🇷 San Martin, Argentina

Sanatorio Diagnóstico; 🇦🇷 Santa Fe, Argentina

Hospital de Messejana Dr. Carlos Alberto Studart Gomes; 🇧🇷 Fortaleza, Brazil

Hospital Copa D'or; 🇧🇷 Rio de Janeiro, Brazil

Amphia Ziekenhuis; 🇳🇱 Breda, Netherlands

GA Research Associates Ltd.; 🇨🇦 Moncton, New Brunswick, Canada

Government Medical College & Hospital; 🇮🇳 Nagpur, India

Jahn Ferenc Del-Pest Hospital; 🇭🇺 Budapest, Hungary

Fejer County Saint George University Teaching Hospital; 🇭🇺 Szekesfehervar, Hungary

Clemenshospital; 🇩🇪 Münster, Germany

Katholisches Klinikum Mainz; 🇩🇪 Mainz, Germany

Beijing Luhe Hospital Capital Medical University; 🇨🇳 Beijing, China

Peterborough Regional Health Centre; 🇨🇦 Peterborough, Ontario, Canada

Spaarne Ziekenhuis; 🇳🇱 Haarlem, Netherlands

Sir Gangaram Hospital; 🇮🇳 New Delhi, India

Magyar Honvedseg Egeszsegugyi Kozpont; 🇭🇺 Budapest, Hungary

Universitätsklinikum Regensburg; 🇩🇪 Regensburg, Germany

Somogy County Kaposi Mor Teaching Hospital; 🇭🇺 Kaposvar, Hungary

University Debrecen Hospital; 🇭🇺 Debrecen, Hungary

Kardiologische Praxis Papenburg; 🇩🇪 Papenburg, Germany

Toyota Memorial Hospital; 🇯🇵 Aichi, Toyota, Japan

Kamalnayan Bajaj Hospital; 🇮🇳 Aurangabad, India

Eternal Heart Care Centre & Research Institute Pvt. Ltd.; 🇮🇳 Jaipur, India

KEM Hospital and Seth G S Medical College; 🇮🇳 Mumbai, India

Semmelweis University; 🇭🇺 Budapest, Hungary

Hiroshima General Hospital; 🇯🇵 Hatsukaichi, Japan

Ambulantes Herzzentrum Kassel; 🇩🇪 Kassel, Germany

Lausmed Kft. Outpatient Unit of Internal Medicine; 🇭🇺 Baja, Hungary

IJsselland Ziekenhuis; 🇳🇱 Capelle Aan Den Ijssel, Netherlands

KLES Dr.Prabhakar Kore Hospital and Medical Research Centre; 🇮🇳 Belagavi, India

Sion Hospital (Lokmanya Tilak Municipal Hospital); 🇮🇳 Mumbai, India

Yonsei University Wonju Severance Christian Hospital; 🇰🇷 Wonju-si, Korea, Republic of

Kaplan Medical Center; 🇮🇱 Rehovot, Israel

Csongrad Megyei Eu. Ellato Kozp. Hodmezovasarhely-Mako; 🇭🇺 Hodmezovasarhely, Hungary

University of Szeged; 🇭🇺 Szeged, Hungary

Klinikum Frankfurt Höchst GmbH; 🇩🇪 Frankfurt/Main, Germany

Ishikawa Prefectural Central Hospital; 🇯🇵 Ishikawa, Kanazawa, Japan

Narayana Institute of Cardiac Sciences; 🇮🇳 Bangalore, India

Rijnstate Hospital; 🇳🇱 Arnhem, Netherlands

Ogaki Municipal Hospital; 🇯🇵 Gifu, Ogaki, Japan

Shaare Zedek Medical Center, Jerusalem 91031; 🇮🇱 Jerusalem, Israel

Hiroshima Prefectural Hospital; 🇯🇵 Hiroshima, Hiroshima, Japan

Rabin Medical Center Beilinson; 🇮🇱 Petah Tikva, Israel

St. Imre Hospital, Budapest; 🇭🇺 Budapest, Hungary

Hadassah Medical Center, Ein-Karem; 🇮🇱 Jerusalem, Israel

Bacs-Kiskun Megyei Onkormanyzat Hospital; 🇭🇺 Kecskemet, Hungary

Medizinische Hochschule Hannover; 🇩🇪 Hannover, Germany

Juntendo University Shizuoka Hospital; 🇯🇵 Izunokuni, Japan

St. Luke's International Hospital; 🇯🇵 Tokyo, Chuo-ku, Japan

Assaf Harofe Medical Center; 🇮🇱 Beer Yaacov, Israel

Yokohama City University Medical Center; 🇯🇵 Kanagawa, Yokohama, Japan

Tokushima Prefectural Central Hospital; 🇯🇵 Tokushima, Japan

Bnei Zion Medical Center, Haifa; 🇮🇱 Haifa, Israel

Alrijne Ziekenhuis; 🇳🇱 Leiden, Netherlands

Isala Zwolle; 🇳🇱 Zwolle, Netherlands

NZOZ Pro-Cordis Sopockie Centrum Bad. Kardiolog.; 🇵🇱 Gdynia, Poland

Mazowiecki Szpital Specjalistyczny im. dr Jozefa Psarskiego; 🇵🇱 Ostroleka, Poland

Spitalul Clinic De Urgenta "Prof. Dr. Agrippa Ionescu"; 🇷🇴 Balotesti, Romania

Heart Institute "Niculae Stancioiu", Cluj Napoca; 🇷🇴 Cluj Napoca, Romania

Emergency County Clinical Hospital, Sibiu; 🇷🇴 Sibiu, Romania

Gifu Prefectural General Medical Center; 🇯🇵 Gifu, Gifu, Japan

First City Clinical Hospital named after E. E. Volosevich; 🇷🇺 Arkhangelsk, Russian Federation

Assuta Medical Center; 🇮🇱 Ashdod, Israel

Chungbuk National University Hospital; 🇰🇷 Cheongiu, Korea, Republic of

Seoul National University Bundang Hospital; 🇰🇷 Seongnam, Korea, Republic of

Japanese Red Cross Kumamoto Hospital; 🇯🇵 Kumamoto, Kumamoto, Japan

Noordwest Ziekenhuisgroep; 🇳🇱 Alkmaar, Netherlands

Onze Lieve Vrouwe Gasthuis; 🇳🇱 Amsterdam, Netherlands

Catharina Ziekenhuis; 🇳🇱 Eindhoven, Netherlands

Zuyderland Medisch Centrum; 🇳🇱 Heerlen, Netherlands

Tergooi Ziekenhuis; 🇳🇱 Hilversum, Netherlands

Vasculair Onderzoek Centrum; 🇳🇱 Hoorn, Netherlands

Univ. Clinic Hosp, Bialystok; 🇵🇱 Bialystok, Poland

Nagano Chuo Hospital; 🇯🇵 Nagano, Nagano, Japan

Kagawa Prefectural Central Hospital; 🇯🇵 Takamatsu, Japan

Chungnam National University Hospital; 🇰🇷 Daejoen, Korea, Republic of

Pusan National Univ. Hosp; 🇰🇷 Busan, Korea, Republic of

Meander Medisch Centrum; 🇳🇱 Amersfoort, Netherlands

Universitair Medisch Centrum Groningen; 🇳🇱 Groningen, Netherlands

Medisch Centrum Leeuwarden; 🇳🇱 Leeuwarden, Netherlands

State Healthcare Institution Clinical Hosp. No. 51, Moscow; 🇷🇺 Moscow, Russian Federation

American-Polish Heart Clinic, Lesser Poland Cardiovascular Centre; 🇵🇱 Chorzow, Poland

Spitalul Judetean de Urgenta Braila; 🇷🇴 Braila, Romania

Emergency Clinical Hospital "Bagdasar-Arseni"; 🇷🇴 Bucharest, Romania

Saratov State Med.Univ.n.a.Razumovskogo; 🇷🇺 Saratov, Russian Federation

Medical Academy named after I. Mechnikov, St. Petersburg; 🇷🇺 St. Petersburg, Russian Federation

Showa University Fujigaoka Hospital; 🇯🇵 Yokohama, Japan

Chonnam National University Hospital; 🇰🇷 Gwangju, Korea, Republic of

SC Cardiomed SRL, Iasi; 🇷🇴 Iasi, Romania

Jeroen Bosch Ziekenhuis-Hertogenbosch; 🇳🇱 Hertogenbosch, Netherlands

Tweesteden Ziekenhuis, locatie Tilburg; 🇳🇱 Tilburg, Netherlands

Ziekenhuis Rivierenland; 🇳🇱 Tiel, Netherlands

Silesian Medical University in Katowice; 🇵🇱 Katowice, Poland

4. Military Clinical Hospital with Polyclinic SP ZOZ; 🇵🇱 Wroclaw, Poland

Emergency Clinical County Hospital, Baia Mare; 🇷🇴 Baia Mare, Romania

Elias Emergency Hospital, Bucharest; 🇷🇴 Bucharest, Romania

Spitalul Clinic Judetean, Craiova; 🇷🇴 Craiova, Romania

Regional clinical hospital, Tver; 🇷🇺 Tver, Russian Federation

Saratov Regional Cardiac Center; 🇷🇺 Saratov, Russian Federation

University Hospital in Krakow; 🇵🇱 Krakow, Poland

The John Paul II Hosp.,Dept.of Coronary Heart Disease,Krakow; 🇵🇱 Krakow, Poland

Spitalul Clinic Judetean de Urgenta Brasov; 🇷🇴 Brasov, Romania

Regional Clinical Hospital No.1 n.a. Ochapovskiy, Krasnodar; 🇷🇺 Krasnodar, Russian Federation

Clinical Hospital Center Dr. Dragisa Misovic; 🇷🇸 Belgrade, Serbia

University Clinical Center of Kragujevac; 🇷🇸 Kragujevac, Serbia

General Hospital Leskovac; 🇷🇸 Leskovac, Serbia

Medicome Limited Liability Company; 🇵🇱 Oswiecim, Poland

Instytut Kardiologii, Warszawa; 🇵🇱 Warsaw, Poland

Komi Republican Cardiological Dispensary; 🇷🇺 Syktyvkar, Russian Federation

Emergency University Hospital, Bucharest; 🇷🇴 Bucharest, Romania

Cardiovascular Diseases Institute "Prof. Georgescu", Iasi; 🇷🇴 Iasi, Romania

SC Endodigest SRL; 🇷🇴 Oradea, Romania

L.T. Malaya Institute of Therapy AMS of Ukraine; 🇺🇦 Kharkiv, Ukraine

University Clinical Center of Serbia; 🇷🇸 Belgrade, Serbia

General Hospital Pancevo; 🇷🇸 Pancevo, Serbia

Complejo Hospitalario Universitario de Vigo; 🇪🇸 Vigo, Spain

Minneapolis Heart Institute Foundation; 🇺🇸 Minneapolis, Minnesota, United States

Duke University Medical Center; 🇺🇸 Durham, North Carolina, United States

South Texas Cardiovascular Consultants; 🇺🇸 San Antonio, Texas, United States

Frederiksberg Hospital; 🇩🇰 Frederiksberg, Denmark

Herlev and Gentofte Hospital; 🇩🇰 Herlev, Denmark

People's Hospital of Liaoning Province; 🇨🇳 Shenyang, China

Peking University Shenzhen Hospital; 🇨🇳 Shenzhen, China

Hospital Samaritano; 🇧🇷 Sao Paulo, Brazil

Instituto de Ensino E Pesquisa Do Hospital Da Bahia; 🇧🇷 Salvador, Brazil

Santa Casa de Votuporanga; 🇧🇷 Votuporanga, Brazil

Instituto de Cardiologia Rio Grande do Sul; 🇧🇷 Porto Alegre, Brazil

Grandview Medical Center; 🇺🇸 Birmingham, Alabama, United States

Oklahoma Heart Hospital Research Foundation, Incorporated; 🇺🇸 Oklahoma City, Oklahoma, United States

South Oklahoma Heart Research Group; 🇺🇸 Oklahoma City, Oklahoma, United States

Centennial Heart Cardiovascular Consultants, LLC; 🇺🇸 Nashville, Tennessee, United States

HOP Trousseau; 🇫🇷 Tours, France

Sagamihara Kyodo Hospital; 🇯🇵 Kanagawa, Sagamihara, Japan

Fukuoka Tokushukai Hospital; 🇯🇵 Kasuga, Japan

Saiseikai Kumamoto Hospital; 🇯🇵 Kumamoto, Kumamoto, Japan

Hyogo Brain and Heart Center; 🇯🇵 Hyogo, Himeji, Japan

Kusatsu General Hospital; 🇯🇵 Kusatsu, Japan

Tokyo Bay Urayasu Ichikawa Medical Center; 🇯🇵 Urayasu, Japan

Osaka Police Hospital; 🇯🇵 Osaka, Osaka, Japan

Miyazaki Medical Association Hospital; 🇯🇵 Miyazaki, Japan

Saint-Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine; 🇷🇺 St. Petersburg, Russian Federation

Tyumen Cardiology Center, Dept.of Cardiac Arrhythmia; 🇷🇺 Tyumen, Russian Federation

Ziv Medical Center; 🇮🇱 Safed, Israel

Centro de Investigacion Clinica Coronel Suarez; 🇦🇷 Coronel Suarez, Argentina

Seikeikai New Tokyo Heart Clinic; 🇯🇵 Chiba, Matsudo, Japan

Royal North Shore Hospital; 🇦🇺 St Leonards, New South Wales, Australia

Mercy Gilbert Medical Center; 🇺🇸 Gilbert, Arizona, United States

Arkansas Cardiology, PA; 🇺🇸 Little Rock, Arkansas, United States

Comprehensive Cardiovascular Medical Group; 🇺🇸 Bakersfield, California, United States

Valley Clinical Trials, Inc.; 🇺🇸 Pasadena, California, United States

Cardiovascular Innovation and Research Center; 🇺🇸 Long Beach, California, United States

InvivoCure; 🇺🇸 Mission Hills, California, United States

Interventional Cardiology Medical Group; 🇺🇸 West Hills, California, United States

The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center; 🇺🇸 Torrance, California, United States

Clearwater Cardiovascular Consultants; 🇺🇸 Clearwater, Florida, United States

Integrative Research Associates; 🇺🇸 Fort Lauderdale, Florida, United States

George Washington University Medical Faculty Associates; 🇺🇸 Washington, District of Columbia, United States

University of Florida Health Jacksonville; 🇺🇸 Jacksonville, Florida, United States

Cardiology Partners Clinical Research Institute; 🇺🇸 Palm Beach Gardens, Florida, United States

Cardiovascular Research of Northwest Indiana, LLC; 🇺🇸 Munster, Indiana, United States

Cardiovascular Consultants of South Georgia, LLC; 🇺🇸 Thomasville, Georgia, United States

Atlanta Heart Specialists, LLC; 🇺🇸 Tucker, Georgia, United States

Advanced Heart Care, LLC, Medicoricum, LLC; 🇺🇸 Fairview Heights, Illinois, United States

Midwest Cardiovascular Research and Education Foundation; 🇺🇸 Elkhart, Indiana, United States

Reid Physician Associates; 🇺🇸 Richmond, Indiana, United States

Eastern Maine Medical Center; 🇺🇸 Bangor, Maine, United States

University of Kentucky Medical Center; 🇺🇸 Lexington, Kentucky, United States

Midwest Heart and Vascular Specialists; 🇺🇸 Overland Park, Kansas, United States

Healthy Heart Cardiology; 🇺🇸 Grand Rapids, Michigan, United States

Cardiovascular Specialists of Central Maryland; 🇺🇸 Columbia, Maryland, United States

Shady Grove Adventist Hospital; 🇺🇸 Rockville, Maryland, United States

Michigan Heart, PC; 🇺🇸 Ypsilanti, Michigan, United States

University of Missouri Health System; 🇺🇸 Columbia, Missouri, United States

Mid Michigan Medical Center; 🇺🇸 Midland, Michigan, United States

Western Michigan University; 🇺🇸 Kalamazoo, Michigan, United States

Cardiology Associates Research, LLC; 🇺🇸 Tupelo, Mississippi, United States

Missouri Cardiovascular Specialists, LLP; 🇺🇸 Columbia, Missouri, United States

North Kansas City Hospital; 🇺🇸 North Kansas City, Missouri, United States

Gateway Cardiology, PC; 🇺🇸 Saint Louis, Missouri, United States

St. Louis Heart and Vascular, P.C.; 🇺🇸 Saint Louis, Missouri, United States

AtlantiCare; 🇺🇸 Pomona, New Jersey, United States

Holy Name Medical Center; 🇺🇸 Hackensack, New Jersey, United States

Asheville Cardiology Associates; 🇺🇸 Asheville, North Carolina, United States

Stony Brook University Hospital; 🇺🇸 Stony Brook, New York, United States

Moses H. Cone Memorial Hospital; 🇺🇸 Greensboro, North Carolina, United States

Capital Area Research, LLC; 🇺🇸 Camp Hill, Pennsylvania, United States

Carolina Heart Specialists, LLC; 🇺🇸 Lancaster, South Carolina, United States

Cardiovascular Research of Knoxville; 🇺🇸 Powell, Tennessee, United States

Monument Health; 🇺🇸 Rapid City, South Dakota, United States

Amarillo Heart Clinical Research Institute, Incorporated; 🇺🇸 Amarillo, Texas, United States

Baylor Scott and White Health; 🇺🇸 Plano, Texas, United States

Revival Research Institute, LLC.; 🇺🇸 Sherman, Texas, United States

Cardiovascular Associates of East Texas, PA; 🇺🇸 Tyler, Texas, United States

Fundacion Sanatorio Güemes; 🇦🇷 Ciudad Autonoma Buenos Aires, Argentina

Tidewater Physicians Multispecialty Group; 🇺🇸 Newport News, Virginia, United States

Sentara Hospitals; 🇺🇸 Norfolk, Virginia, United States

Clinica Privada del Prado; 🇦🇷 Cordoba, Argentina

Instituto Cardiovascular de Buenos Aires; 🇦🇷 Belgrano, Argentina

Roanoke Heart Institute PLC; 🇺🇸 Roanoke, Virginia, United States

Hospital Italiano de Córdoba; 🇦🇷 Cordoba, Argentina

Hospital Privado Centro Medico de Cordoba; 🇦🇷 Cordoba, Argentina

Instituto Cardiovascular de Rosario; 🇦🇷 Rosario, Argentina

Fundación Favaloro para la Docencia e Investigación Medica; 🇦🇷 Monserrat, Argentina

Sanatorio Parque; 🇦🇷 Rosario, Argentina

Instituto de Cardiología de Corrientes; 🇦🇷 Corrientes, Argentina

Sanatorio Delta; 🇦🇷 Rosario, Argentina

Centro Privado de Cardiología; 🇦🇷 San Miguel de Tucuman, Argentina

Hospital "Dr. José Maria Cullen"; 🇦🇷 Santa Fé, Argentina

Clinica U.O.M.; 🇦🇷 San Nicolas, Argentina

South Western Sydney Local Health District; 🇦🇺 Liverpool, New South Wales, Australia

Clinica Privada Fusavim SRL; 🇦🇷 Villa Maria, Argentina

Westmead Hospital; 🇦🇺 Westmead, New South Wales, Australia

Gold Coast University Hospital; 🇦🇺 Southport, Queensland, Australia

JMF Clinica Do Coracao LTDA; 🇧🇷 Aracaju - SE, Brazil

Hospital Santa Isabel; 🇧🇷 Balneario Camboriu, Brazil

Hospital Madre Teresa; 🇧🇷 Belo Horizonte, Brazil

Alfred Hospital; 🇦🇺 Melbourne, Victoria, Australia

Hospital do Coracao do Brasil; 🇧🇷 Brasilia, Brazil

Hospital Angelina Caron; 🇧🇷 Campina Grande do Sul, Brazil

Centro Especializado em Cardiol Loema Instituto de Pesq Clin; 🇧🇷 Campinas, Brazil

Hospital Regional Hans Dieter Schmidt; 🇧🇷 Joinville, Brazil

IPECC - Instituto de Pesquisa Clínica de Campinas; 🇧🇷 Campinas, Brazil

HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás; 🇧🇷 Goiania, Brazil

Hospital Nossa Senhora da Conceição; 🇧🇷 Porto Alegre, Brazil

Santa Casa de Misericórdia de Marília; 🇧🇷 Marília, Brazil

Hospital Sao Lucas da PUCRS; 🇧🇷 Porto Alegre, Brazil

Hospital São Vicente de Paulo; 🇧🇷 Passo Fundo, Brazil

Fundacao de apoio ao ensino e assitencia HCFMRP; 🇧🇷 Ribeirao Preto, Brazil

Hospital Agamenon Magalhaes; 🇧🇷 Recife, Brazil

Hospital de Base - Fac Med de Sao Jose do Rio Preto; 🇧🇷 Sao Jose do Rio Preto, Brazil

Multiprofile Hospital for Active Treatment AD Haskovo; 🇧🇬 Haskovo, Bulgaria

Hospital das Clínicas de Sao Paulo - INCOR; 🇧🇷 Sao Paulo, Brazil

Hospital Sao Luiz Jabaquara; 🇧🇷 Sao Paulo, Brazil

Hospital Sao Luiz Morumbi; 🇧🇷 Sao Paulo, Brazil

Multiprofile Hospital For Active Treatment Pulse AD; 🇧🇬 Blagoevgrad, Bulgaria

CEMEC - Centro Multidisciplinar de Estudos Clínicos; 🇧🇷 São Bernardo do Campo, Brazil

Multiprofile Hospital For Active Treatment - Pazardzhik AD; 🇧🇬 Pazardzhik, Bulgaria

Multiprofile Hospital For Active Treatment "Dr. Tota Venkova" AD; 🇧🇬 Gabrovo, Bulgaria

Specialized Hospital for Active Treatment Sv. Georgi - Pernik; 🇧🇬 Pernik, Bulgaria

Hospital MHAT Plovdiv, AD; 🇧🇬 Plovdiv, Bulgaria

Medical Center Medconsult Pleven LTD; 🇧🇬 Pleven, Bulgaria

SHAT in Cardiology EAD, Pleven; 🇧🇬 Pleven, Bulgaria

University Multiprofile Hospital for Active Treatement "Alexandrovska" EAD; 🇧🇬 Sofia, Bulgaria

Multiprofile Hospital for Active Treatment Heart and Brain EAD; 🇧🇬 Pleven, Bulgaria

National Heart Hospital, Sofia; 🇧🇬 Sofia, Bulgaria

Medical Military Academy MHAT Sofia; 🇧🇬 Sofia, Bulgaria

Multiprofile Hospital MHATEM 'Pirogov', Sofia; 🇧🇬 Sofia, Bulgaria

Heritage Medical Research Clinic; 🇨🇦 Calgary, Alberta, Canada

City Clin.Univ.MPHAT EOOD,Clin.of Cardiology, Sofia; 🇧🇬 Sofia, Bulgaria

UMHAT "Tsaritsa Yoannalsul"; 🇧🇬 Sofia, Bulgaria

Hospital Trakia Park; 🇧🇬 Stara Zagora, Bulgaria

MHAT Sv.Anna, Clinic of Internal Diseases, Sofia; 🇧🇬 Sofia, Bulgaria

University of Alberta Hospital (University of Alberta); 🇨🇦 Edmonton, Alberta, Canada

Royal Alexandra Hospital; 🇨🇦 Edmonton, Alberta, Canada

Royal Inland Hospital; 🇨🇦 Kamloops, British Columbia, Canada

Surrey Memorial Hospital; 🇨🇦 Surrey, British Columbia, Canada

QEII Health Sciences Centre; 🇨🇦 Halifax, Nova Scotia, Canada

Queen's University; 🇨🇦 Kingston, Ontario, Canada

William Osler Health Centre; 🇨🇦 Brampton, Ontario, Canada

Southlake Regional Health Centre; 🇨🇦 Newmarket, Ontario, Canada

Centre Hospitalier de l'Universite de Montreal (CHUM); 🇨🇦 Montreal, Quebec, Canada

Heart Health Institute; 🇨🇦 Scarborough, Ontario, Canada

Montreal Heart Institute; 🇨🇦 Montreal, Quebec, Canada

Montreal General Hospital - McGill University Health Centre; 🇨🇦 Montreal, Quebec, Canada

IUCPQ (Laval University); 🇨🇦 Sainte-Foy, Quebec, Canada

CSSS du Sud de Lanaudiere - Hopital Pierre-Le Gardeur; 🇨🇦 Terrebonne (Lachenaie), Quebec, Canada

McGill University Health Centre (MUHC); 🇨🇦 Montreal, Quebec, Canada

CIUSSS de l Estrie-CHUS; 🇨🇦 Sherbrooke, Quebec, Canada

Oakville Trafalgar Memorial Hospital; 🇨🇦 Oakville, Canada

CIUSSS de la Mauricie-et-du-Centre-du-Quebec; 🇨🇦 Trois-Rivieres, Quebec, Canada

Beijing Chao-Yang Hospital; 🇨🇳 Beijing, China

Chinese PLA General Hospital; 🇨🇳 Beijing, China

China-Japan Friendship Hospital; 🇨🇳 Beijing, China

Shulan(Hanghzhou) Hospital; 🇨🇳 Hangzhou, China

The First Affiliated Hospital of Harbin Medical University; 🇨🇳 Haerbin, China

Changsha Central Hospital; 🇨🇳 Changsha, China

Guangdong Provincial People's Hospital; 🇨🇳 Guangzhou, China

Xiangya Hospital, Central South University; 🇨🇳 Changsha, China

Zhejiang Hospital; 🇨🇳 Hangzhou, China

Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine; 🇨🇳 Hangzhou, China

CHU Rouen; 🇫🇷 Rouen Cedex, France

Zhongshan Hospital Fudan University; 🇨🇳 Shanghai, China

The Second Affiliated Hospital of Lanzhou Medical University; 🇨🇳 Lanzhou, China

Aalborg Universitetsshospital; 🇩🇰 Aalborg, Denmark

Aarhus University Hospital; 🇩🇰 Aarhus N, Denmark

Renmin Hospital of Wuhan University; 🇨🇳 Wuhan, China

HOP Bichat; 🇫🇷 Paris, France

Rigshospitalet; 🇩🇰 Copenhagen, Denmark

Slagelse Sygehus; 🇩🇰 Slagelse, Denmark

HOP Sud Francilien; 🇫🇷 Corbeil Essonnes, France

Hospital de Saint Joseph et Saint Luc; 🇫🇷 Lyon, France

HOP CHU de Grenoble; 🇫🇷 Grenoble Cedex 9, France

CHRU Lille; 🇫🇷 Lille, France

HOP Brabois; 🇫🇷 Vandoeuvre-lès-Nancy, France

SLK-Kliniken Heilbronn GmbH; 🇩🇪 Bad Friedrichshall, Germany

Kerckhoff-Klinik, Bad Nauheim; 🇩🇪 Bad Nauheim, Germany

Charité - Universitätsmedizin Berlin; 🇩🇪 Berlin, Germany

St. Johannes Hospital Dortmund; 🇩🇪 Dortmund, Germany

Universitätsklinikum Bonn AöR; 🇩🇪 Bonn, Germany

Bremer Institut für Herz- und Kreislaufforschung (BIHKF) am Klinikum Links der Weser; 🇩🇪 Bremen, Germany

Universitätsklinikum Frankfurt; 🇩🇪 Frankfurt am Main, Germany

Städtisches Klinikum Dresden; 🇩🇪 Dresden, Germany

Klinikum Coburg gGmbH; 🇩🇪 Coburg, Germany

Universitätsklinikum Leipzig; 🇩🇪 Leipzig, Germany

Universitäts-Herzzentrum Freiburg, Bad Krozingen GmbH; 🇩🇪 Freiburg I. Breisgau, Germany

Asklepios Kliniken GmbH & Co. KGaA; 🇩🇪 Hamburg, Germany

Buda Hospital of the Hospitaller Order of Saint John of God; 🇭🇺 Budapest, Hungary

Jasz-Nagykun-Szolnok Megyei Hetenyi G. Korhaz-Rendelointezet; 🇭🇺 Szolnok, Hungary

Zala County Hospital, Zalaegerszeg; 🇭🇺 Zalaegerszeg, Hungary

Pest Megyei Flor Ferenc Hospital; 🇭🇺 Kistarcsa, Hungary

Sri Jayadeva Institute of Cardiovascular Sciences & Research; 🇮🇳 Bangalore, India

Barzilai Medical Center; 🇮🇱 Ashkelon, Israel

Haemek Medical Center; 🇮🇱 Afula, Israel

Soroka Univ. Medical Center; 🇮🇱 Beer Sheba, Israel

The Chaim Sheba Medical Center Tel HaShomer; 🇮🇱 Ramat Gan, Israel

Hillel Yaffe Medical Center, Hadera; 🇮🇱 Hadera, Israel

Lady Davis Carmel Medical Center; 🇮🇱 Haifa, Israel

Kasugai Municipal Hospital; 🇯🇵 Aichi, Kasugai, Japan

Rambam Medical Center; 🇮🇱 Haifa, Israel

Meir Medical Center; 🇮🇱 Kfar-Saba, Israel

West.Galilee Med.Cent.Naharia; 🇮🇱 Nahariya, Israel

Baruch Padeh Medical Center; 🇮🇱 Tiberias, Israel

Chibanishi General Hospital; 🇯🇵 Chiba, Matsudo, Japan

Sourasky Medical Center; 🇮🇱 Tel Aviv, Israel

Saiseikai Fukuoka General Hospital; 🇯🇵 Fukuoka, Fukuoka, Japan

Tsuchiura Kyodo General Hospital; 🇯🇵 Ibaraki, Tsuchiura, Japan

Tokai University Hospital; 🇯🇵 Kanagawa, Isehara, Japan

Bucheon Sejong Hospital; 🇰🇷 Bucheon, Korea, Republic of

Amsterdam UMC Locatie VUMC; 🇳🇱 Amsterdam, Netherlands

Admiraal de Ruyter Ziekenhuis; 🇳🇱 Goes, Netherlands

American Heart of Poland; 🇵🇱 Belchatow, Poland

Leids Universitair Medisch Centrum (LUMC); 🇳🇱 Leiden, Netherlands

American Heart of Poland Sp. z o.o.; 🇵🇱 Tychy, Poland

Podhalanski Special.Hosp,Intern.Med&Cardiology Dept,Nowy Tag; 🇵🇱 Nowy Targ, Poland

Dr Alfred Sokołowski Specialist Hospital; 🇵🇱 Walbrzych, Poland

Central Hospital of Medical Academy, Warsaw; 🇵🇱 Warsaw, Poland

Jan Mikulicz-Radecki UnivClinic Hosp,Cardiology Dept,Wroclaw; 🇵🇱 Wroclaw, Poland

Military Central Clinical Emergency Hospital; 🇷🇴 Bucharest, Romania

Prof.C.C.Iliescu Hospital, National Institute of Cardiology; 🇷🇴 Bucharest, Romania

Regional Clinical Hospital, Kirov; 🇷🇺 Kirov, Russian Federation

Institute for Cardiovascular diseases Dedinje; 🇷🇸 Belgrade, Serbia

Reg.Clin.Hosp.n.a.Semashko; 🇷🇺 Nizhniy Novgorod, Russian Federation

Republic Kareliya Republican Hosp. named after V.A. Baranov; 🇷🇺 Petrozavodsk, Russian Federation

Penza Regional Clinical Hospital named after N.N.Burdenko; 🇷🇺 Penza, Russian Federation

GUZ Ryazanskiy Regional Clin. Cardiology Dispensary, Ryazan; 🇷🇺 Ryazan, Russian Federation

Samara Regional Clinical Cardiology Clinic, Day Hosp. Dept.; 🇷🇺 Samara, Russian Federation

State Budg.Healthc.Instit Volgograd RegClin.Cardiology Centr; 🇷🇺 Volgograd, Russian Federation

Institute for Treatment and Rehabilitation, Niska Banja; 🇷🇸 Niska Banja, Serbia

Institute of Cardiovascular Diseases; 🇷🇸 Sremska Kamenica, Serbia

General Hospital Sremska Mitrovica; 🇷🇸 Sremska Mitrovica, Serbia

Health Center Uzice; 🇷🇸 Uzice, Serbia

General Hospital - Djordje Joanovic; 🇷🇸 Zrenjanin, Serbia

University Hospital of Bellvitge; 🇪🇸 Barcelona, Spain

Health Centre Zajecar; 🇷🇸 Zajecar, Serbia

Hospital Universitario 12 de Octubre; 🇪🇸 Madrid, Spain

Hospital Germans Trias i Pujol; 🇪🇸 Badalona, Spain

Hospital Universitari Joan XXIII; 🇪🇸 Tarragona, Spain

Cherkasy Regional Cardiological Center; 🇺🇦 Cherkasy, Ukraine

City Joint Emergency Hospital, Dnepropetrovsk; 🇺🇦 Dnepropetrovsk, Ukraine

Ivano-Frankivsk City Central Clinical Hospital; 🇺🇦 Ivano-Frankivsk, Ukraine

CI of Healthcare Kharkiv CCH #8, Kharkiv; 🇺🇦 Kharkiv, Ukraine

Khmelnytskyi Regional Hospital; 🇺🇦 Khmelnytskyi, Ukraine

Clinical Medical Diagnostic Center Simedgroup; 🇺🇦 Ivano-Frankivsk, Ukraine

Reg.Clin.Hosp.Non-Commercial Enterprise; 🇺🇦 Kharkiv, Ukraine

SI NSC M.D. Strazhesko Institute Cardiology of NAMSU, Kyiv; 🇺🇦 Kiev, Ukraine

Lutsk City Clinical Hospital; 🇺🇦 Lutsk, Ukraine

Odesa Regional Clinical Hospital; 🇺🇦 Odesa, Ukraine

Kiev Emergency Care Hospital; 🇺🇦 Kiev, Ukraine

Communal Noncommercial Enterprise of Lviv Regional Council "Lviv Regional Clinical Psychiatric Hospital"; 🇺🇦 Lviv, Ukraine

Transcarpathian Regional Clinical Center; 🇺🇦 Uzhgorod, Ukraine

Zhytomyr Regional Clinical Hospital, Dept. Endocrinology; 🇺🇦 Zhytomyr, Ukraine

Independent Public Healthcare, Dept. of Cardiology, Pulawy; 🇵🇱 Pulawy, Poland

Cardiology and Cardiovascular Rehabilitation Clinic; 🇷🇴 Timisoara, Romania

City Clinical Hospital No. 1, Kiev; 🇺🇦 Kiev, Ukraine

Max Superspeciality Hospital; 🇮🇳 New Delhi, India

Sahyadri Speciality Hospital; 🇮🇳 Pune, India

Victoria Heart Institute Foundation; 🇨🇦 Victoria, British Columbia, Canada

Centrul Medical Cardiomed; 🇷🇴 Targu-Mures, Romania

Clinical Medical Center Zvezdara, Belgrade; 🇷🇸 Belgrade, Serbia

University Clinical Center Nis; 🇷🇸 Nis, Serbia

General Hospital Subotica, Internal Medicine; 🇷🇸 Subotica, Serbia

Vancouver General Hospital; 🇨🇦 Vancouver, British Columbia, Canada

University of Louisville; 🇺🇸 Louisville, Kentucky, United States

The University of North Carolina at Chapel Hill; 🇺🇸 Chapel Hill, North Carolina, United States

Concord Repatriation General Hospital; 🇦🇺 Concord, New South Wales, Australia

The Prince Charles Hospital; 🇦🇺 Chermside, Queensland, Australia

St. Boniface Hospital; 🇨🇦 Winnipeg, Manitoba, Canada

Instituto de Cardiologia de Corrientes; 🇦🇷 Corrientes, Argentina

Centro Privado de Cardiologia; 🇦🇷 San Miguel de Tucuman, Argentina

Nanjing Drum Tower Hospital; 🇨🇳 Nanjing, China

Peking University First Hospital; 🇨🇳 Beijing, China