Assessment of the Psychological, Cognitive and Social Resources of Applicants for Huntington's Disease and Presymptomatic Genetic Testing

Not Applicable

Completed

• Conditions: Presymptomatic Huntington Disease
• Interventions: Behavioral: psychological interview; Radiation: MRI; Other: cognitive tests; Other: neurological tests

• Registration Number: NCT02134561
• Lead Sponsor: University Hospital, Angers

Brief Summary

The purpose of this study is to assess the psychological, cognitive and social resources of applicants for Huntington's Disease and Presymptomatic Testing.

Detailed Description

Not available

Study Timeline

• Status Verified: 2013-02
• Study Start: 2013-09
• Study First Submitted: 2014-04-10
• Study First Submitted QC: 2014-05-06
• Study First Posted: 2014-05-09
• Primary Completion: 2018-08
• Study Completion: 2018-08
• Last Update Submitted: 2020-10-20
• Last Update Posted: 2020-10-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Applicants for Huntington's Disease and Presymptomatic Testing
• Aged 18 years and above
• Huntington disease family member
• Subject gave its written consent

Exclusion Criteria

• No national health insurance affiliation
• Being under guardianship
• Meeting brain MRI exclusion criteria (pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin, or body, Renal failure, hypersensitivity of Gadolinium) or refusing MRI.
• Patient with movement disorder

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
All subjects	neurological tests	psychological interview, MRI, neurological tests, cognitive tests
All subjects	cognitive tests	psychological interview, MRI, neurological tests, cognitive tests
All subjects	psychological interview	psychological interview, MRI, neurological tests, cognitive tests
All subjects	MRI	psychological interview, MRI, neurological tests, cognitive tests

Primary Outcome Measures

Name	Time	Method
Change from baseline total score of the psychological Unified Huntington's Disease Rating Scale at 2 years	3 months before diagnostic (baseline) ; 2 years after diagnostic,

Trial Locations

Locations (1)

University Hospital of Angers; 🇫🇷 Angers, Pays De La Loire, France