Everyday social behaviour and mood in individuals with a family history of depressio

Completed

Conditions: Depression
Mood disorder
10027946

Registration Number: NL-OMON39507

Lead Sponsor: Rijksuniversiteit Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

• Age 18-65 years
• At least one first-degree family member with MDD
• Willingness to cooperate; to sign written informed consent

Exclusion Criteria

• Any current or past MDD or other mood disorder as determined by the SCID-NP
• Any current anxiety disorder, psychotic disorder, substance use disorder, eating disorder, or somatoform disorder as determined by SCID-NP
• Any contraindication for the use of tryptophan, i.e. pregnancy, diabetes, cancer or a history of cancer, a history of any scleroderma-like condition, evidence of achlorhydria, upper bowel malabsorption, or irritation of the urinary bladder
• Current use of psychotropic medications including medications for psychiatric problems (e.g., antidepressants such as MAO inhibitors and fluoxetine) or migraines
• Not speaking Dutch fluently

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary outcome is the level of quarrelsome behaviour measured using ecological<br /><br>momentary assessment. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcome measures include levels of agreeable, dominant, and<br /><br>submissive behaviours, as well as affect, cognitions, and perceptions. Finally,<br /><br>polymorphisms of genes thought to be related to MDD may be determined.</p><br>