REGARD: Comparing regional and general anaesthesia and their effect on delirium in patients with hip fractures
- Conditions
- Specialty: Injuries and emergencies, Primary sub-specialty: Injuries and emergenciesUKCRC code/ Disease: Injuries and Accidents/ Injuries to the hip and thighInjury, Occupational Diseases, PoisoningInjuries to the hip and thigh
- Registration Number
- ISRCTN15165914
- Lead Sponsor
- niversity of Warwick
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 100
1. Clinically or radiographically diagnosed intracapsular or extracapsular hip fracture
2. Planned surgical treatment via hemiarthroplasty, total hip arthroplasty or appropriate fixation procedure
3. Aged 65 years and over
1. Multiple trauma or planned concurrent surgery not amenable to spinal anaesthesia
2. Absolute contraindication to regional anaesthesia:
2.1. Known or suspected congenital or acquired coagulopathy
2.2. Active use of pharmacological anticoagulants within a timeframe defined to contraindicate neuraxial block placement
2.3. Known or suspected unrepaired critical or severe aortic stenosis
2.4. Known or suspected active skin infection at the planned needle insertion site
2.5. Known or suspected elevated intracranial pressure contraindicating dural puncture; previous spinal surgery precluding RA, localised sepsis in lumbar spine, documented allergies to local anaesthetic
3. Known or suspected to be at elevated risk for malignant hyperthermia
4. Previous participation in the REGARD trial
5. Determination by the surgeon or the anaesthetist that the patient would not be suitable for randomisation
6. Patient not expected to survive beyond 48 hours
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method