Factors Associated With Interdialytic Blood Pressure Variability in Maintenance Hemodialysis Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Kidney Failure, Chronic
- Sponsor
- Beijing Chao Yang Hospital
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- interdialytic blood pressure
- Last Updated
- 13 years ago
Overview
Brief Summary
The purpose of this study is to explore the factors associated with interdialytic blood pressure variability in maintenance hemodialysis patients, especially the association between volume status and blood pressure variability.
Detailed Description
Hemodialysis patients experience higher rates of cardiovascular morbidity and mortality than the general population and many populations with other chronic diseases. This exceptional risk is explained in part by known risk factors such as diabetes, hypertension, and other uremia-related factors, including vascular calcification and stiffness, autonomic dysfunction, and a high burden of circulating inflammatory mediators. However, additional unidentified risk factors also likely contribute to the disproportionately high prevalence of cardiovascular morbidity in hemodialysis patients. Blood pressure variability may represent one plausible cardiovascular risk factor. Data from nonuremic human populations show an association between greater blood pressure variability and cardiovascular events,nonfatal cardiovascular events,stroke,and increased left ventricular mass. There has been comparatively little work examining the causes and effects of blood pressure variability in hemodialysis populations. So the purpose of this study is to explore the factors associated with interdialytic blood pressure variability in maintenance hemodialysis patients, especially the association between volume status and blood pressure variability.
Investigators
Ma Weihua
Principal Investigater
Beijing Chao Yang Hospital
Eligibility Criteria
Inclusion Criteria
- •age 18 years or older
- •receipt of thrice-weekly in-center hemodialysis
- •no anticipation of imminent(\<6 months)living related kidney transplant
- •not transfer of care to a nonparticipating facility
- •no dialytic modality change
- •free of vascular, infectious, or bleeding complication within 1 month
Exclusion Criteria
- •who missed \>2 hemodialysis treatments over 1 month
- •abused drugs
- •severe anemia，malnutrition，chronic atrial fibrillation
- •body mass index of 40 \>kg/m2
Outcomes
Primary Outcomes
interdialytic blood pressure
Time Frame: 44 hours
Ambulatory BP monitoring was performed after the midweek hemodialysis session for 44 hours. Ambulatory BPs were recorded every 20 minutes during the day (6 AM to 10 PM) and every 30 minutes during the night (10 PM to 6 AM) in the nonaccess arm, We use the coefficient of variation or standard deviation in interdialytic blood pressure as a indicator of systolic blood pressure variability.