Y402H Comlement Factor H Polymorphism and Age-Related Macular Degeneration in the Austrian Population

Not Applicable

• Conditions: Age-Related Macular Degeneration

• Registration Number: NCT00533754
• Lead Sponsor: Rudolf Foundation Clinic

Brief Summary

The aim of the study is to show a higher expression of the Y402H polymorphism in the complement factor H in patients with AMD compared to healthy individuals.

Additionaly a correlation between a subsided infection with chlamydia and patients with AMD and a factor H polymorphism will be investigated. An interrelationship with the VEGF-plasma level shall give more hints into the pathomechanism of AMD.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-07
• Status Verified: 2007-09
• Study First Submitted: 2007-09-20
• Study First Submitted QC: 2007-09-20
• Last Update Submitted: 2007-09-20
• Study First Posted: 2007-09-21
• Last Update Posted: 2007-09-21
• Study Completion: 2007-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• man and women over 18 years old
• Filled out informed consentBereitschaft zur Teilnahme
• Diagnosis of non-exudative/ exudative age related macular dgeneneration

Exclusion Criteria

• inherited retinal diseases
• other aquired retinal/ macular
• missing informed consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
higher expression of the Y402H polymorphism in the complement factor H in patients with AMD compared to healthy individuals

Secondary Outcome Measures

Name	Time	Method
a correlation between a subsided infection with chlamydia and patients with AMD and a factor H polymorphism will be investigated. An interrelationship with the VEGF-plasma level shall give more hints into the pathomechanism of AMD

Trial Locations

Locations (1)

Rudoulf foundation Clinic; 🇦🇹 Vienna, Austria