Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy

Hospices Civils de Lyon2 个研究点分布在 1 个国家目标入组 40 人开始时间: 2004年12月1日最近更新: 2007年3月12日

适应症

试验速览

阶段: 4 期
发起方: Hospices Civils de Lyon
入组人数: 40
试验地点: 2
主要终点: To evaluate the effect of perioperative ketalar on pain intensity 3 months after a mastectomy

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Prevalence of chronic pain after mastectomy is beyond 50% 3 months after surgery. This pain is related to a sensitization of the central nervous system through N-methyl-D-asparate (NMDA) receptors. Ketalar might prevent the occurrence of chronic pain by anti-NMDA properties after mastectomy.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Parallel
主要目的: Treatment
盲法: Double

入排标准

年龄范围: 18 Years 至 80 Years（Adult, Older Adult）
性别: Female
接受健康志愿者: 否

入选标准

•Mastectomy in patients 18 to 80 years old

排除标准

•American Society of Anesthesiology (ASA) class >= 3
•Renal, heart or hepatic failure
•Allergy to ketalar
•Psychiatric disease
•Chronic antalgic treatment

结局指标

主要结局

To evaluate the effect of perioperative ketalar on pain intensity 3 months after a mastectomy

Pain intensity is evaluated by an appropriate questionnaire 1 and 3 months after surgery.

次要结局

To evaluate the incidence of chronic pain after mastectomy, the impact on life quality, and the area of hyperalgesia

研究者

发起方

Hospices Civils de Lyon

申办方类型

Other

研究点 (2)

Loading locations...

相似试验

已完成

不适用

The Effects of Anesthetics on Persistent Pain Following Breast Cancer SurgeryChronic Post-Procedural PainBreast Cancer

NCT03782896Samsung Medical Center89

已完成

3 期

Administration of Ketamine to Prevent the Post-operative PainPostoperative PainBreast Cancer

NCT00210210Institut Bergonié230

已完成

1 期

Prevention of Post Mastectomy With Intraoperative KetaminePain, PostoperativePost-Mastectomy Chronic Pain Syndrome

NCT03090776Brigham and Women's Hospital264

已完成

不适用

Prediction of Persistent Post-Mastectomy PainChronic Pain

NCT02329574Brigham and Women's Hospital259

已完成

不适用

Surgical Treatment of Post-surgical Mastectomy Pain Utilizing the Regenerative Peripheral Nerve InterfacePost-Mastectomy Chronic Pain Syndrome

NCT04530526University of Michigan Rogel Cancer Center26