Exercise, Cognitive Function and Neuroplasticity in Healthy Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- Change in cortical synaptic plasticity using transcranial magnetic stimulation (TMS) from baseline to post-exercise.
研究概览
简要总结
The overall goal of the proposed study is to compare the effects of 4 weeks of moderate or high intensity aerobic exercise on neuroplasticity, cognitive performance and gait and postural control in sedentary healthy adults.
详细描述
The primary aim of the study is to compare the effects of a moderate intensity aerobic exercise intervention (delivered at 55-64% age-predicted maximal heart rate) with a high intensity aerobic exercise intervention (delivered at 65%-90% age-predicted maximal heart rate) on measures that probe cortical synaptic plasticity using transcranial magnetic stimulation (TMS) in sedentary healthy adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult males and females aged 18-70 years old
- •Primary language is English
- •Sedentary (defined as not engaging in purposeful physical activity more than 2 times over the last two months)
- •Exercise clearance
排除标准
- •Presence of cognitive, neurologic or orthopedic conditions that could affect performance of the testing and training procedures
- •History of migraines.
- •History of fainting spells of unknown or undetermined etiology that might constitute seizures
- •History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or family history of treatment resistant epilepsy
- •Any current history of a psychiatric illness
- •Any unstable medical condition
- •No medication is an absolute exclusion from TMS. Medications will be reviewed by the Principal Investigator and a decision about inclusion will be made based on the following:
- •The subject's past medical history, drug dose, history of recent medication changes or duration of treatment, and combination with other CNS active drugs.
- •The published TMS guidelines review medications to be considered with TMS (Rossi, Hallett, Rossini, Pascual-Leone, & Safety of TMS Consensus Group, 2009).
- •Any metal in the brain, skull or elsewhere unless approved by the responsible MD
- •Any medical devices (i.e. Cardiac pacemaker, deep brain stimulator, medication infusion pump, cochlear implant, vagal nerve stimulator)
- •Intracranial lesion
- •Substance abuse or dependence within the past six months Subjects who, in the Investigator's opinion, might not be suitable for the study
研究组 & 干预措施
Moderate intensity exercise.
Moderate intensity aerobic exercise intervention (delivered at 55-64% age-predicted maximal heart rate), 4 times per week for 4 weeks.
干预措施: Moderate intensity exercise. (Behavioral)
High intensity exercise
High intensity aerobic exercise intervention (delivered at 65%-90% age-predicted maximal heart rate), 4 times per week for 4 weeks.
干预措施: High intensity exercise. (Behavioral)
结局指标
主要结局
Change in cortical synaptic plasticity using transcranial magnetic stimulation (TMS) from baseline to post-exercise.
时间窗: Baseline, 4 weeks
Plasticity with TMS
次要结局
未报告次要终点
研究者
Joyce Rios Gomes Osman
Assistant Professor
University of Miami