An Epidemiological Study on Antimicrobial Treatment of Nosocomial Infections in Clinical Practice
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- AstraZeneca
- 入组人数
- 1,500
- 试验地点
- 1
- 主要终点
- The number and percentage of subjects with nosocomial infection received appropriate antimicrobial treatment
研究概览
简要总结
The present study is a retrospective cohort study on patients who suffered a nosocomial infection in major hospitals in Vietnam. Data relating to patient demography include age, gender; medical history; APACHE II score; background conditions, infection details and antimicrobial therapy; and all-caused mortality, time of hospitalization and intensive care. The investigators hypothesis is that antimicrobial treatment inappropriate is highly dependent on incidence of antibiotic resistant pathogens, nonfermentative Gram-negative bacilli and ESBL-producing enterobacteriaceae spp. Variables are demographic characteristics, background conditions, immunosuppressive therapy, antimicrobial susceptibility and inappropriate treatment is explored as possible predictors of mortality.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient was diagnosed as nosocomial infection defined according to criteria established by the US CDC. The diagnosis criteria for ventilator-associated pneumonia are modified from those established by the American College of Chest Physicians.
- •Patient received empiric antimicrobial therapy within 24 hour from onset of infection and had antimicrobial susceptibility.
排除标准
- •A patient was in part of a controlled clinical trial for the current infection episode.
- •Patients with suspected infections by virus or fungus or tuberculosis will be excluded.
结局指标
主要结局
The number and percentage of subjects with nosocomial infection received appropriate antimicrobial treatment
时间窗: 30 days as from onset of nosocomial infection
次要结局
- The number and percentage of patients with nosocomial infections received de-escalation therapy(30 days as from onset of nosocomial infection)
- The number and percentage of hospital mortality, the number of days for hospitalization, intensive care among groups of patients who received appropriate or inappropriate antimicrobial treatments(30 days as from onset of nosocomial infection)
- The determinants for inappropriate antimicrobial treatment and mortality.(30 days as from onset of nosocomial infection)