2024-515946-17-00进行中（未招募）3 期
IFCT-1805 ELDERLY Phase III randomized trial of atezolizumab in elderly patients with advanced Non-Small-Cell Lung Cancer and receiving monthly carboplatin with weekly paclitaxel chemotherapy
Intergroupe Francophone De Cancerologie Thoracique68 个研究点 分布在 1 个国家目标入组 510 人开始时间: 2019年7月23日最近更新:
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 510
- 试验地点
- 68
- 主要终点
- Overall survival
研究概览
简要总结
To determine the activity of anti-PDL1 antibody ATEZOLIZUMAB in elderly patient in first line treatment by measuring overall survival probability in patients treated in the standard arm versus overall survival probability in the experimental arm (atezolizumab + carboplatin and paclitaxel)
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 65 years 至 65+ years（65+ Years）
- 接受健康志愿者
- 否
入选标准
- •Signed Written Informed Consent: - Subjects must have signed and dated an IRB/IEC approved written informed consent form in accordance with regulatory and institutional guidelines. This must be obtained before the performance of any protocol related procedures that are not part of normal subject care. - Subjects must be willing and able to comply with scheduled visits, treatment schedule, and laboratory testing
- •Life expectancy of at least 12 weeks
- •For male patients with female partners of childbearing potential, agreement (by patient and/or partner) to use a highly effective form(s) of contraception that results in a low failure rate [ 1% per year] when used consistently and correctly, and to continue its use for 6 months after the last dose of treatment. Male patients should not donate sperm during this study and for at least 6 months after the last dose of treatment. Oral contraception should always be combined with an additional contraceptive method because of a potential interaction with the treatment. Male patients must always use a condom.
- •Patient covered by a national health insurance
- •Protected adults can participate if they are able to make decision about their medical treatment according to guardianship judgment.
- •Histologically confirmed NSCLC. A cytologically-proven NSCLC is allowed if a cytoblock has been prepared.
- •Age: 70 to 89 years
- •Performance status ≤
- •Stage IIIB or IIIC non irradiable or IV (8th classification TNM, UICC 2015)
- •Measurable disease as defined by RECIST 1.
- •The radiological assessment has to be done within the timelines indicated.
- •No prior systemic anticancer therapy (including EGFR or ALK inhibitors) given as primary therapy for advanced or metastatic disease. Previously irradiated lesion must not be the only measurable site of disease.
- •At least 3 weeks must have elapsed after major surgery or radiation therapy
- •Adequate biological functions: Creatinine Clearance ≥ 45 mL/min (Cockroft or MDRD or CKD-epi); neutrophiles ≥ 1500/mm3 ; platelets ≥100 000/mm3 ; Hemoglobin ≥ 9g/dL ; hepatic enzymes < 3x ULN except for patients with hepatic metastases (< 5 x ULN), total bilirubine ≤ 1,5 x ULN except for patients with proved, Gilbert syndrome (≤ 5 x ULN) or patients with hepatic metastases (≤ 3,0 mg/dL).
排除标准
- •Small cell lung cancer or tumors with mixt histology including a SCLC component
- •Symptomatic brain metastases requiring corticosteroids.
- •Spinal cord compression not definitely treated by surgery and/or radiation therapy or with neurological sequelae.
- •Leptomeningeal disease
- •Uncontrolled tumor-related pain.
- •Uncontrolled or symptomatic or requiring Denosumab hypercalcemia.
- •Corticosteroids > 10mg oral prednisone/day or equivalent.
- •Immunosuppressive medications within 2 weeks before randomization
- •History of idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced pneumonitis, idiopathic pneumonitis, or evidence of active pneumonitis on screening chest CT scan. History of radiation pneumonitis in the radiation field (fibrosis) is permitted.
- •HIV positive serology (test at screening)
- •Patients with active hepatitis B (chronic or acute; defined as having a positive hepatitis B surface antigen HBsAg test at screening) or hepatitis C Patients with past hepatitis B virus (HBV) infection or resolved HBV infection (defined as the presence of hepatitis B core antibody [HBcAb] and absence of HBsAg) or past or resolved hepatitis C virus (HCV) infection are eligible.
- •Known EGFR activating tumor mutation
- •Active tuberculosis
- •Severe infection within 4 weeks before randomization
- •Received therapeutic oral or iv antibiotics within 2 weeks before randomization.
- •Administration of live attenuated vaccine within four weeks before randomization or anticipation that such a live attenuated vaccine will be required during the study.
- •Serious undergoing diseases or comorbidities precluding the possibility for the patient to receive the treatments including but not limited to unstable angina or uncontrolled cardiac disease.
- •Polyneuropathy ≥ grade 2 CTC
- •Treatment with an investigational drug during the 4 weeks preceding inclusion in the trial.
- •Known allergy to Cremophor EL
- •Known ALK or ROS1 gene rearrangement as assessed by IH, FISH or NGS sequencing
- •Previous or active cancer within the previous 3 years with the exception of those with a negligible risk of metastasis or death and treated with expected curative outcome (such as adequately treated carcinoma in situ of the cervix, basal cell skin cancer or ductal carcinoma in situ treated surgically with curative intent. For other type of cancer, please contact IFCT). Patients with a prostate adenocarcinoma history within the previous 3 years could be included in case of localized prostate cancer, with good prognostic factors according to d'Amico classification (≤ T2a and Score de Gleason ≤ 6 and PSA (ng/ml) ≤ 10), provided they were treated in a curative way (surgery or radiotherapy ± hormonotherapy, without any chemotherapy)
- •Mini Mental Score < 24
- •Previous systemic treatment (including but not limited to chemotherapy, targeted treatment or immunotherapy) except for adjuvant therapy given more than 5 years ago.
- •History of severe allergic, anaphylactic, or other hypersensitivity reactions to chimeric or humanized antibodies or fusion proteins
- •Known hypersensitivity or allergy to biopharmaceuticals produced in Chinese hamster ovary cells or any component of the atezolizumab formulation
- •History of autoimmune disease, including but not limited to myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus, inflammatory bowel disease, vascular thrombosis associated with antiphospholipid syndrome, Wegener’s granulomatosis, Sjögren’s syndrome, Guillain-Barré syndrome, multiple sclerosis, vasculitis, or glomerulonephritis Patients with a history of autoimmune-related hypothyroidism on a stable dose of thyroid replacement hormone are eligible for this study. Patients with rheumatoid arthritis without exacerbation during one year and with no more than 10 mg oral prednisone /day or equivalent may be included after rheumatologist advice. Patients with controlled Type 1 diabetes mellitus on a stable dose of insulin regimen are eligible for this study Patients with eczema, psoriasis, lichen simplex chronicus, or vitiligo with dermatologic manifestations only (e.g., patients with psoriatic arthritis would be excluded) are permitted provided that they meet the following conditions: - Rash must cover less than 10% of body surface area (BSA). - Disease is well controlled at baseline and only requiring low potency topical steroids. - No acute exacerbations of underlying condition within the previous 12 months (not requiring PUVA [psoralen plus ultraviolet A radiation], methotrexate, retinoids, biologic agents, oral calcineurin inhibitors, high-potency or oral steroids)
结局指标
主要结局
Overall survival
Overall survival
次要结局
- Progression-free survival
- Best overall response rate
- Duration of response
研究者
Contact
Scientific
Intergroupe Francophone De Cancerologie Thoracique
研究点 (68)
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