Macular Pigment Measurements in Eye & Other Tissues
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 10,000
- 试验地点
- 2
- 主要终点
- Carotenoid levels in the skin
研究概览
简要总结
The purpose of this study is to understand the role of nutrition and its effects on the eye and other tissues. The investigators propose to study this by validating and correlating various non-invasive measurement methods of carotenoid concentrations in the human eye and skin tissue.
A secondary objective is to correlate blood levels of carotenoids on a sub-set of participants.
详细描述
The macula of the human retina (the structure responsible for high acuity vision essential for reading, driving and recognizing faces) is colored an intense yellow due to the deposition of two carotenoid compounds, lutein and zeaxanthin. These xanthophyll carotenoids are derived exclusively from the diet, and are hypothesized to protect the macula from light-induced oxidative damage by virtue of their light-screening and antioxidant properties.
Epidemiological studies have shown that high dietary intake and blood levels of lutein and zeaxanthin are associated with lower rates of vision loss due to age-related macular degeneration (AMD).
It is of interest to correlate carotenoid levels in the eye and skin tissues with blood levels of carotenoid compounds.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 7 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Any patient age 7 or older, undergoing routine dilated ophthalmology examinations at the Moran Eye Center will be eligible to participate.
- •Patients with adult vitelliform dystrophy. (This condition initially presents in adulthood as bilateral subtle and often asymptomatic macular lesions, which are often misdiagnosed as early age-related macular degeneration (AMD)).
排除标准
- •Patients under age 7 will not be eligible to participate.
研究组 & 干预措施
Carotenoid measurements
Subjects are asked to have carotenoid levels measured in the eye, skin and/or blood.
干预措施: Carotenoid measurements (Other)
结局指标
主要结局
Carotenoid levels in the skin
时间窗: at enrollment
all study procedures are generally completed in a single study visit
Carotenoid levels in the eye
时间窗: at enrollment
all study procedures are generally completed in a single study visit
次要结局
- Carotenoid levels in the blood(at enrollment)
研究者
Paul S. Bernstein
Professor, Ophthalmology/Visual Sciences
University of Utah