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Clinical Trials/NCT07016217
NCT07016217Active, not recruitingNot Applicable

Impact Evaluation of the Therapeutics Initiative's Mailed Dental Portrait and Therapeutics Letter

University of British Columbia1 site in 1 country3,498 target enrollmentStarted: May 15, 2023Last updated:
Conditions
Interventions

Trial Snapshot

Phase
Not Applicable
Status
Active, not recruiting
Enrollment
3,498
Locations
1
Primary Endpoint
Intention to treat analysis

Study Overview

Brief Summary

The goal of this randomized trial is to estimate the impact of personalized prescribing portraits and educational materials on prescribing of antibiotic medications by dentists in British Columbia, Canada.

The main research question is:

Did the prescribing Portraits and Therapeutics Letter lead to a change in clindamycin prescribing as a proportion of total antibiotic prescribing by dentists in British Columbia.

Study participants are dentists actively practicing in British Columbia. Participants were randomized to 3 study arms to received different combinations of one of two versions of the individual prescribing Portraits and a Therapeutics Letter in Early or Delayed Groups. Two versions of the prescribing Portrait were used: a "plain" version and a "complete" version, which included an additional section with self-reflection questions for clinicians.

Using administrative health data, the prescribing of those in different combinations of materials in the Early Group will be compared to those in the Delayed Group to estimate the impact of the materials on prescribing by the dentists.

Detailed Description

Audit and feedback is a well-established strategy for improving the quality of care in primary healthcare settings. It involves the systematic collection and analysis of healthcare data, followed by the provision of information to healthcare providers to improve the quality of care.

Based in British Columbia, Canada, the Therapeutics Initiative's Portrait program provides physicians, and other health professionals, with individualized prescribing data compared with their peers, paired with evidence-based messaging, and a concise statement summarizing the desired change in prescribing behavior. The Portrait program implements a series of pragmatic trials to improve prescribing where clinicians are randomized into an early intervention and a delayed control group.

This study is a randomized trial examining the impact of prescribing Portraits on antibiotic prescribing by dentists in British Columbia. The Portrait title is "Which antibiotics do you prescribe for dental infections?" and is accompanied by a Therapeutics Letter entitled "Rethink Clindamycin for Dental Patient Safety." The materials were developed in collaboration with the BC Centre for Disease Control (BCCDC) and the BC College of Oral Health Professionals (BCCOHP).

When dentists prescribe antibiotics like clindamycin for dental infections, they often do so with the intention of combating bacterial growth. However, clindamycin come with a set of risks, notably the potential for Clostridium difficile infection (C. diff). This bacterium can proliferate in the gut when the normal balance of bacteria is disrupted by antibiotics, leading to symptoms ranging from mild diarrhea to severe colitis and life-threatening complications.

The main prescribing message for the dental Portrait is "clindamycin should not be used routinely for prophylaxis or management of dental infections." The Portrait has two different formats. The "plain" version includes the main message, prescriber's data (compare to optimal prescribing), and references. The "complete" version includes an additional series of self-reflection questions.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Sequential
Primary Purpose
Health Services Research
Masking
Single (Participant)

Eligibility Criteria

Ages
16 Years to — (Child, Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •Dentists registered with the BC College of Oral Health Professionals with an active dental practice in BC
  • •Dentists in BC included in randomization groups 1-3 with at least 10 prescription orders filled for antibiotics in 2022
  • •Patients aged >16
  • •Patient prescribed antibiotic therapy by a BC dentist during, before, or after periods; Anatomical Therapeutic Chemical (ATC) classes J01
  • •Patient was enrolled in MSP at least 1 month before the prescription

Exclusion Criteria

  • •Dentists not registered with the BC College of Oral Health Professionals
  • •Dentists with fewer than 10 prescription orders filled in 2022
  • •Patients used antibiotics in the last 14 days (prescribed by any prescriber, not only dentists) before the prescription; and
  • •Federally insured BC residents and beneficiaries of the First Nations Health Benefit Plan; we were not given permission to use these data in our evaluation

Arms & Interventions

Arm A (Group 1) - Portrait + Letter

Experimental

This group received the "plain" Portrait with a Therapeutics Letter in the Early mailing (Oct 13, 2023), and received the "complete" Portrait with a Therapeutics Letter in the Delayed mailing (April 24, 2024).

Intervention: Early Plain Portrait and Letter (Behavioral)

Arm A (Group 1) - Portrait + Letter

Experimental

This group received the "plain" Portrait with a Therapeutics Letter in the Early mailing (Oct 13, 2023), and received the "complete" Portrait with a Therapeutics Letter in the Delayed mailing (April 24, 2024).

Intervention: Delayed Complete Portrait (Behavioral)

Arm B (Group 2) - Portrait + Letter

Experimental

This group received the "complete" Portrait with a Therapeutics Letter in the Early mailing (Oct 13, 2023), and received nothing in the Delayed mailing (April 24, 2024).

Intervention: Early Complete Portrait and Letter (Behavioral)

Arm C (Group 3) - Control

Experimental

This group received nothing in the Early mailing (Oct 13, 2023) and received the "plain" Portrait with a Therapeutics Letter in the Delayed mailing (April 24, 2024).

Intervention: Delayed Plain Portrait and Letter (Behavioral)

Arm C (Group 3) - Control

Experimental

This group received nothing in the Early mailing (Oct 13, 2023) and received the "plain" Portrait with a Therapeutics Letter in the Delayed mailing (April 24, 2024).

Intervention: No intervention (Behavioral)

Arm B (Group 2) - Portrait + Letter

Experimental

This group received the "complete" Portrait with a Therapeutics Letter in the Early mailing (Oct 13, 2023), and received nothing in the Delayed mailing (April 24, 2024).

Intervention: No intervention (Behavioral)

Outcomes

Primary Outcomes

Intention to treat analysis

Time Frame: Assessed from the baseline until the early intervention (6 months) to 6 months after the delayed intervention (total of 18 months).

The primary outcome is the change in clindamycin prescribing (number of new starts) as a proportion of total antibiotic prescribing associated with the interventions.

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Colin Dormuth

Associate Professor

University of British Columbia

Study Sites (1)

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