NCT00002003已完成2 期
Phase II Study of Novantrone(R) (Mitoxantrone) and Etoposide in Patients With HIV Associated Large Cell and Immunoblastic Lymphomas
适应症
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 试验地点
- 6
研究概览
简要总结
To determine the efficacy and toxicity of the combination of mitoxantrone hydrochloride ( Novantrone ) and etoposide in the treatment of patients with HIV associated lymphomas.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients must have the following:
- •Positive HIV antibody, positive HIV culture or antigen capture, or prior diagnosis of AIDS by the CDC criteria.
- •Diagnosis by pathological examination of large cell or immunoblastic lymphoma within measurable or evaluable disease.
- •Pneumocystis carinii pneumonia (PCP) prophylaxis during the course of the study.
- •Signed written informed consent.
排除标准
- •Co-existing Condition:
- •Patients with the following conditions or symptoms are excluded:
- •Acute intercurrent opportunistic infection, such as Pneumocystis carinii pneumonia (PCP) diagnosed within 3 weeks.
- •Stage IE Central Nervous System lymphomas.
- •Patients with the following are excluded:
- •More than one previous treatment for lymphoma.
- •Acute intercurrent opportunistic infection, such as Pneumocystis carinii pneumonia (PCP) diagnosed within 3 weeks.
- •Conditions that preclude obtaining an informed consent.
- •Not accessible for scheduled treatment visits or follow-up.
- •Stage IE Central Nervous System (CNS) lymphomas.
- •Prior Medication:
- •Excluded within 2 weeks of study entry:
- •Zidovudine.
- •Excluded:
- •Doxorubicin dosing = or > 300 mg/m
- •Prior Treatment:
- •Received more than one previous treatment regimen for lymphoma.
- •Prophylactic treatment for Pneumocystis carinii pneumonia (PCP) prophylaxis.
研究者
研究点 (6)
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