Post-operative Infusion of Intra-operative Cell Salvage Reduces Allogeneic Blood Product Transfusions and Volume Resuscitation in Pediatric Cardiac Surgery and Improves Clinical Outcomes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 106
- 试验地点
- 2
- 主要终点
- Comparison of volume of allogeneic blood products and crystalloid/colloid infusions between groups
研究概览
简要总结
Transfusion of washed intra-operative cell salvage post-operatively in the PCICU can be performed safely without increased risk of bleeding or release of inflammatory mediators. This will reduce the need for allogeneic blood products as well as crystalloid and colloid infusions and thus decrease the length of ventilation and intensive care duration for these infants.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Weight < or = 20Kg;
- •Cardiac surgery with CPB at URMC;
- •informed consent
排除标准
- •weight > 21 Kg;
- •inability to obtain consent;
- •non-English speaking
结局指标
主要结局
Comparison of volume of allogeneic blood products and crystalloid/colloid infusions between groups
时间窗: 2 years
To compare the volume of allogeneic blood products and crystalloid/colloid infusions between patients randomized to receive washed intra-operative cell salvage vs our current standard for volume replacement for the first 24 hours post-op
次要结局
- comparison of bleeding, use of coagulant products, and inflammatory markers between groups(2 years)
- comparison of clinical outcomes between groups(2 years)
研究者
jill cholette
Assistant Professor of Pediatrics
University of Rochester