Investigating Neural Processing of Social Stimuli: Investigating a Neurobehavioral Mechanism of Paranoia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 试验地点
- 2
- 主要终点
- Resting cerebral blood flow (CBF)
研究概览
简要总结
The primary goal of the present study is to test whether neural activity in brain regions associated with processing threat and social stimuli may underlie paranoid thinking.
详细描述
Paranoia is a prominent symptom of psychosis that occurs in several other diagnoses, as well as the general population, and that is associated with significant distress and impairment. Previous research suggests that increased baseline activity of the amygdala and related neural circuits may serve as a mechanism for paranoid ideation. This exploratory study will use a paranoia induction procedure in healthy individuals who vary in pre-existing levels of paranoid ideation to test whether increases in self-reported paranoia are accompanied by increases in resting cerebral blood flow (CBF), decreased stimulus-driven neural activity in social processing networks, and increased behavioral perceptions of untrustworthiness.
Participants will be randomly assigned to participate in a paranoia induction procedure or a control condition and will then complete neuroimaging and behavioral assessments.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •between the ages of 18 and 55
排除标准
- •current psychiatric diagnosis
- •current use of psychotropic medications
- •history of head trauma with loss of consciousness for more than 15 minutes
- •presence of neurological or neurodegenerative disorder
- •sensory impairments that preclude assessment
- •presence of intellectual disability
- •contraindications for MRI (e.g., metallic implants or pregnancy)
结局指标
主要结局
Resting cerebral blood flow (CBF)
时间窗: CBF measurements will be obtained during the study visit and will last approximately 9 minutes.
CBF in amygdala and related neural circuits
次要结局
- Self-reported paranoid ideation(Data will be obtained during the study visit and will last approximately 5 minutes.)
- Amount of Neural Activity(Measurements will be obtained during the study visit and will last approximately 25 minutes.)
- Ratings of Trustworthiness(Data will be obtained during the study visit and will last approximately 12 minutes.)
研究者
Amy Pinkham
Associate Professor
The University of Texas at Dallas