Observational Prospective Study.at the End of the Study the Patients Will be Classified According to PH,Serum Bicarbonate and Serum Sodium Into 6 Groups and Statistical Analysis Will be Performed Using Spss

Completed

• Conditions: Liver Cirrhosis
• Interventions: Diagnostic Test: arterial blood gases and serum electrolytes

• Registration Number: NCT05082064
• Lead Sponsor: Sohag University

Brief Summary

1-to identify the prognostic value of serum bicarbonate and serum electrolytes at time of admission and their association with development of complications ,length of hospital stay ,prognosis and mortality in hospitalized cirrhotic patient

Detailed Description

the purpose of this study will be explore the impact of data obtained for the arterial blood gas parameters and serum bicarbonate and electrolytes at the time of hospital admission on adverse clinical outcomes ,duration of length of hospital stay and mortality in patients with cirrhosis .Furthermore incorporation these parameters into model of end stage liver disease could help to improve the prognostic value of MELDscore in comparison to the prognostic value of traditional equation of original MELD and child score

Study Timeline

• Study First Submitted: 2021-09-10
• Study First Submitted QC: 2021-10-05
• Study Start: 2021-10-08
• Study First Posted: 2021-10-18
• Primary Completion: 2022-12-08
• Status Verified: 2023-01
• Study Completion: 2023-01-07
• Last Update Submitted: 2023-01-07
• Last Update Posted: 2023-01-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 121

Inclusion Criteria

patients with confirmed diagnosis of cirrhosis (age >18 years ) who will be admitted to internal medicine department or will be admitted to intermediate care unit

• willing and agree to be included in the study

Exclusion Criteria

• patients without evidence of cirrhosis

• cirrhotic patients whom -younger than 18 years old

  • have diabetic ketoacidosis
  • with acute coronary syndrome
  • with fulminant liver failure
  • with heart failure
  • with organ transplantation
  • when arterial blood gases not be available
  • patient refusal
  • patient with HCC

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
MELD group B	arterial blood gases and serum electrolytes	Group B\>25
MELD-PACO2 Group C	arterial blood gases and serum electrolytes	Group C\<25
MELD-BICARBONATE Group F	arterial blood gases and serum electrolytes	Group F\>23
MELD -PACO2 Group D	arterial blood gases and serum electrolytes	Group D\>25
MELD score group A	arterial blood gases and serum electrolytes	MELD score :group A\<25
MELD-BICARBONATE score Group E	arterial blood gases and serum electrolytes	Group E\<23

Primary Outcome Measures

Name	Time	Method
will be ICU admitted	from the day of admission to the day of discharge from hospital or death during hospitalization	will be admitted to ICU due to progression of the disease; complications as shok,hepatorenal syndrome,severe infection,starting renal replacement therapy and icu intervention as mechanical ventilation using MELD score and child score depending on ABGparameters and serum electrolytes .

Trial Locations

Locations (1)

Heba Allah fadel abd elrahman; 🇪🇬 Sohag, Egypt