Effect of Sulfur Thermal Water on Circulating H2S Levels and Markers of Bone Metabolism in Osteopenic Subjects.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Measurement of biomarkers of bone turnover, marker #2
研究概览
简要总结
The aim of the study is to investigate whether inhalation treatment with high-sulfide waters from some spas (referred to as "thermal waters"), performed for 12 consecutive days, is able to change circulating H2S levels and alter bone metabolism. Identifying a clear correlation between circulating levels of H2S and sulfur water administration, as well as a potential anabolic effect on bone, would set the stage for new studies that could have important clinical implications for promoting health and preventing osteoporosis
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •post-menopausal women with a diagnosis of osteopenia
排除标准
- •concurrent muscoloskeletal conditions or chronic pharmacological treatment interfering with bone metabolism
研究组 & 干预措施
Bone turnover markers
Concentrations of bone turnover markers will be assessed before and after treatment. Correlation will be sought for with H2S levels and clinical features of the patients
干预措施: inhalatory treatment with sulfureous aerosol (Other)
结局指标
主要结局
Measurement of biomarkers of bone turnover, marker #2
时间窗: 15 days
Bone-specific alkaline phosphatase (BAP), marker of bone formation
Measurement of biomarkers of bone turnover, marker #3
时间窗: 15 days
serum C-terminal telopeptide of type I collagen (CTX-1), marker of bone resorption
Measurement of biomarkers of bone turnover, marker #1
时间窗: 15 days
Procollagen type 1 N-terminal propeptide (P1NP), marker of bone formation
次要结局
- Measurement of serum H2S levels(15 days)