Treatment in the Rotterdam Early Arthritis CoHort: a stratified, randomised clinical trial in patients with recent-onset arthritis

Erasmus Medical Centre (Netherlands)0 个研究点目标入组 568 人开始时间: 2007年8月23日最近更新: 2021年8月17日

适应症

试验速览

2009 Protocol article in http://www.ncbi.nlm.nih.gov/pubmed/19538718 protocol 2012 Results article in http://www.ncbi.nlm.nih.gov/pubmed/22673898 results 2014 Results article in http://www.ncbi.nlm.nih.gov/pubmed/24788619 1-year results 2016 Results article in http://www.ncbi.nlm.nih.gov/pubmed/27283332 results 2019 Results article in https://www.ncbi.nlm.nih.gov/pubmed/31242943 results on association between DNA methylation and methotrexate response (added 28/06/2019) 2018 Results article in https://www.ncbi.nlm.nih.gov/pubmed/29760159 results (added 12/08/2019) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33484138/ results on correlation between risk factors and clinical course (added 25/01/2021) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33725091/ results on cost utility (added 17/03/2021) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/34352094/ results on DMARD-free remission (added 06/08/2021)

•1. Participant of the REACH cohort (patients with inflammatory joint complaints less then one year)
•2. All patients must at least have one (out of 66) swollen joint
•Added 23/04/2009:
•3. Aged 18 years or older, either sex

•1. Definite diagnosis of crystal arthropathy, (post) infective arthritis or autoimmune rheumatic disorder
•2. Previous therapy with disease modifying anti-rheumatic drugs (DMARDs) or corticosteroids
•3. Pregnancy or wish to become pregnant during the study, or childbearing potential without adequate contraception
•4. Concomitant treatment with an other experimental drug
•5. History or presence of malignancy within the last five years
•6. Elevated hepatic enzyme levels (aspartate aminotransferase [ASAT], alanine aminotransferase [ALAT] greater than two times normal value)
•7. Thrombopoenia less than 150 x 10^9/l
•8. Leucopoenia less than 3.0 x 10^9/l
•9. Serum creatinine level greater than 150 umol/l

发起方

Erasmus Medical Centre (Netherlands)