The effects of recurrent hypoglycaemia in healthy males aged between 18 and 35 years on gastric emptying, glucose absorption, autonomic nerve function, cardiac function, glucagon, pancreatic polypeptide and catecholamine secretion.

Associate Professor Adam Deane0 个研究点目标入组 12 人开始时间: 2014年9月12日最近更新: 2021年7月5日

适应症

试验速览

暂无简介。

•Exclusion criteria will comprise:
•*Radiation exposure for research purposes in the past 12 months;
•*History of diabetes;
•*HbA1c >6.0%;
•*Impaired renal function;
•*Creatinine clearance <100 ml/min;
•*Hb <130 g/L
•*Taking medication that are known to effect gastrointestinal motility;
•*Taking medication effecting blood glucose;
•*Previous surgery on the stomach or small intestine;
•*History of autonomic neuropathy;
•*Smoking >10 cigarettes per day;
•*Alcohol >20g per day;
•*History of cardiac disease ;
•*History of cardiac arrhythmias;
•*ECG abnormalities;
•*Because of concerns of cumulative life time exposure to radiation, we will directly screen all volunteers as to their previous radiation exposure, and will exclude any volunteer who has received 3 or more examinations using a computerized tomogram and/or 10 or more examinations using standard x-rays.
•*Previous surgery on the autonomic nervous system (eg sympathectomy)
•*Previous surgery on the adrenal glands
•*History of seizures or seizure disorders
•*History of migranes

发起方

Associate Professor Adam Deane