Reducing infection risk in adult patients with acute leukemia using modified donor lymphocyte infusion (DLI) following allogeneic hematopoietic stem cell transplantatio
Phase 1
Not yet recruiting
- Conditions
- Acute leukemia.Acute leukemia of unspecified cell typeC95.0
- Registration Number
- IRCT20230801058996N4
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
Transplantation of T cell replete haplotype with cyclophosphamide
The estimated life expectancy more than one year
Karnofsky index above 70%
Exclusion Criteria
GVHD of grade 2 or less
Uncontrolled bacterial infection
Insufficient intake: WBC<2500/mm3 and Platelet<50000/mm3
Evidence of recurrence
Concomitant treatment with corticosteroids and/or other immunosuppressive drugs
Infection with hepatitis B, C and HIV pathogens
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method