Personalized Medicine for Diabetes Prediction and Prevention of Complications
- Conditions
- Metabolic SyndromeDiabetes
- Interventions
- Other: Breath analysis and blood analysis
- Registration Number
- NCT01268813
- Lead Sponsor
- Rambam Health Care Campus
- Brief Summary
The metabolic syndrome is a collection of related risk factors that predispose to the development of type 2 diabetes Mellitus and cardiovascular disease. The investigators will examine the hypothesis that the metabolic and genomic characteristics of patients with metabolic syndrome and/or diabetes that are at risk for developing complications differ from each other and can be detected using specific biomarkers in blood or in the exhaled breath. Early detection of these individuals will enable personalized treatment to prevent and treat diabetes and its complications
- Detailed Description
Breath samples will be collected in inert respiratory bag from diabetic and healthy volunteers, and analyzed using a chamber containing nano-chemical sensors. These samples together with blood samples will additionally be characterized using Gas Chromatography-Mass Spectroscopy "GC-MS".
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
- Metabolic Syndrome
- Type 2 diabetes
- Healthy volunteers with 20<Body Mass Index<25
- Smoking
- Chronic or acute lung disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Exhaled breath uptake blood test Breath analysis and blood analysis Diabetic patients receiving oral hypoglycemic drug will be tested for biomarkers in their breath and blood samples Exhaled breath and blood test Breath analysis and blood analysis Breath and blood samples will be collected from healthy volunteers and analyzed using Gas Chromatography-Mass Spectroscopy. The results will be compared to the experimental arm.
- Primary Outcome Measures
Name Time Method Development of Diabetes or complication 2 years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Rambam Medical Center - Inst. Endocrinology, Diabetes & Metabolism
🇮🇱Haifa, Israel