NCT00305474Unknown4 期
Identification and Treatment of the Liability to Develop Schizophrenia
Central South University1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2003年12月最近更新:
适应症
相关药物
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Neuropsychological - cognitive measures
研究概览
简要总结
This study seeks to determine whether adult, non-psychotic, first-degree relatives of schizophrenic patients who show specific neurocognitive deficits and negative symptoms will show improvements in these areas following a 6-month, double-blind trial of a low dose (up to 2.0 mg) of risperidone.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 19 Years 至 59 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Having at least one first-degree biological relative with schizophrenia and their age is between 19 and
- •Desire to participate in a medication trial.
- •Is able to provide informed consent.
- •Having moderate levels of negative symptoms, defined as 6 items rated 3 or higher on the Scale for the Assessment of Negative Symptoms (SANS).
- •Scoring two or more standard deviations below normal in at least one of three cognitive domains: vigilance/working memory, long-term verbal memory, and executive functions.
- •Scoring at least one standard deviation below normal in a second cognitive domain.
排除标准
- •IQ less than
- •Formal education less than 10 years.
- •History of psychotic disorders.
- •History of treatment with an antipsychotic medication.
- •A substance abuse diagnosis within 6 months of diagnosis.
- •A head injury with documented loss of consciousness exceeding 5 minutes (or subsequent cognitive deficits).
- •A history of neurologic disease or damage.
- •A medical condition with significant cognitive sequelae.
- •A history of electroconvulsive treatment.
结局指标
主要结局
Neuropsychological - cognitive measures
时间窗: 2003-2010
次要结局
- Psychiatric Symptoms(2003-2010)
研究者
研究点 (1)
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