Effect of Different Exercises on Quality of Life of Leukemia Patients.

Not Applicable

Completed

• Conditions: Acute Lymphoblastic Leukemia; Exercise; Quality of Life
• Interventions: Behavioral: Aerobic exercises; Behavioral: Modified strength training

• Registration Number: NCT03147365
• Lead Sponsor: Children's Cancer Hospital Egypt 57357

Brief Summary

* To compare between modified strength training program and aerobic exercises on quality of life on children with Acute Lymphoblastic Leukemia.

* To compare between modified strength training program and aerobic exercises on functional capacity on children with Acute Lymphoblastic Leukemia.

Detailed Description

This study will be done to determine any exercise from aerobic exercises or modified strength training program will be more effective on quality of life and functional capacity on children with Acute Lymphoblastic Leukemia .Acute Lymphoblastic Leukemia is wide spread in the world and the children with this disease are fragile so must know the most program effect.

Study Timeline

• Study Start: 2017-03-05
• Study First Submitted: 2017-04-02
• Study First Submitted QC: 2017-05-07
• Study First Posted: 2017-05-10
• Primary Completion: 2019-12-27
• Status Verified: 2020-01
• Study Completion: 2020-04-05
• Last Update Submitted: 2020-07-20
• Last Update Posted: 2020-07-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• Age range from8-12years.
• Children during 3rd phase( maintenance phase of the treatment). According San et al(2007) who found children with Acute Lymphoblastic Leukemia in maintenance phase of treatment can safely perform both aerobic and resistance training .
• Time elapsed since the start of the maintenance phase >20weeks.
• Children with muscle weakness due to chemotherapy.
• The height , weight and body mass index of the child will take on standard scale.
• preserved cardiac structure and function as assisted by echo-cardiogram.
• The children have ability to walk.

Exclusion Criteria

Children who have one or more of the following criteria will be excluded from the study:

• Receiving more intensive chemotherapy.
• Mental disabled.
• Sever cardiomyopathy (ejection fraction <40%, ECG will be used as a pretest as it might be a more sensitive tool to exclude angina pectoris).
• Low blood platelet levels (< 50.000 per µl).
• Marked anemia (hemoglobin < 8 g/dl).
• Severe cachexia (i.e., weight mass loss > 35%).
• Pain in bone.
• Inability to walk.
• Sensory disturbance.
• Peripheral neuropathy.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Study group A	Aerobic exercises	Twenty five children who will receive physical therapy treatment which include aerobic exercises.
Study group B	Modified strength training	Twenty five children who will receive physical therapy treatment which include modified strength training program.

Primary Outcome Measures

Name	Time	Method
Improvement of quality of life	at week 20	The pediatric quality of life inventory (PedsQL) is a modular approach to measure health-related quality of life in healthy children and adolescents and those with acute and chronic health conditions.

Secondary Outcome Measures

Name	Time	Method
Improvement of functional capacity	at week 20	6 minute walk test is a test to measure functional capacity by using pulse oximeter to detect percentage of oxygen saturation at peripheral capillaries.

Trial Locations

Locations (1)

Children's Cancer Hospital Egypt 57357; 🇪🇬 Cairo, Egypt