Vasopressor Support, Mean Arterial Pressure and Capillary Refill Time in Critically Ill Patients

Recruiting

• Conditions: Critical Illness
• Interventions: Diagnostic Test: Capillary refill time

• Registration Number: NCT05674084
• Lead Sponsor: Medical University of Silesia

Brief Summary

The goal of this observational study is to learn whether different doses of various vasopressor drugs influence capillary refill time (CRT) value in crtically ill patients. The main questions it aims to answer are:

* How do vasopressor drugs determine CRT value

* How does mean arterial pressure (MAP) determine CRT value

* How often CRT value is normal (\< 3 sec) despite hypotensive MAP (\<65 mmHg)

Participants will have the CRT measured over the course of the ICU hospitalization. At the end of the study, multiple linear regression will be performed to verify whether different doses of vasopressor drugs influence CRT value.

Detailed Description

The goal of this observational study is to learn whether different doses of various vasopressor drugs influence capillary refill time (CRT) value in critically ill patients. The main questions it aims to answer are:

* How does norepinephrine dose influence CRT value

* How does epinephrine dose influence CRT value

* How does argipressin dose influence CRT value

* How does dobutamine dose influence CRT value

* How does mean arterial pressure (MAP) determine CRT value

* How often CRT value is normal (\< 3 sec) despite hypotensive MAP (\<65 mmHg)

Participants will have the CRT measured over the course of the ICU hospitalization. At the end of the study, multiple linear regression will be performed to verify whether different doses of vasopressor drugs influence CRT value. CRT will be a dependent variable. Independent variables will be as follows: age, MAP, norepinephrine dose, epinephrine dose, argipressin dose, dobutamine dose.

CRT measurements will be performed in a standarized rigor (light, chronometer, pressure and ambient temperature will be the same in all patients)

Study Timeline

• Status Verified: 2022-12
• Study Start: 2022-12-03
• Study First Submitted: 2022-12-11
• Study First Submitted QC: 2022-12-21
• Last Update Submitted: 2022-12-21
• Study First Posted: 2023-01-06
• Last Update Posted: 2023-01-06
• Primary Completion: 2023-10-31
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• critical illness requiring vasopressor support
• invasive blood pressure monitoring

Exclusion Criteria

• finger distal phalanx not available
• patient in a room of suboptimal ambient temperature

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Study group	Capillary refill time	Critically ill patients undergoing any vasopressor treatment. CRT will be measured over the course of hospitalization. Maximal number of CRT measurements from a single patient is limited to 5.

Primary Outcome Measures

Name	Time	Method
Effect of norepinephrine dose on CRT value	Through study completion, an average of 1 year	In a multiple linear regression, it will be verified whether different doses of norepinephrine determine CRT value.
Effect of mean arterial pressure on CRT value	Through study completion, an average of 1 year	In a multiple linear regression, it will be verified whether different values of MAP determine CRT value.

Secondary Outcome Measures

Name	Time	Method
Effect of dobutamine dose on CRT value	Through study completion, an average of 1 year	In a multiple linear regression, it will be verified whether different doses of dobutamine determine CRT value.
Effect of argipressin dose on CRT value	Through study completion, an average of 1 year	In a multiple linear regression, it will be verified whether different doses of argipressin determine CRT value.
CRT value in MAP <65 mmHg	Through study completion, an average of 1 year	It will be analyzed whether in hypotensive conditions (MAP \<65 mmHg), CRT values are normal (\< 3 sec)
Effect of epinephrine dose on CRT value	Through study completion, an average of 1 year	In a multiple linear regression, it will be verified whether different doses of epinephrine determine CRT value.

Trial Locations

Locations (1)

University Clinical Center named after prof. K. Gibiński of the Medical University of Silesia in Katowice; 🇵🇱 Katowice, Silesia, Poland