Influence of Vasopressor Support and Mean Arterial Pressure on Capillary Refill Time Values in Critically Ill Patients: Prospective, Observational Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Critical Illness
- Sponsor
- Medical University of Silesia
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- Effect of norepinephrine dose on CRT value
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
The goal of this observational study is to learn whether different doses of various vasopressor drugs influence capillary refill time (CRT) value in crtically ill patients. The main questions it aims to answer are:
- How do vasopressor drugs determine CRT value
- How does mean arterial pressure (MAP) determine CRT value
- How often CRT value is normal (< 3 sec) despite hypotensive MAP (<65 mmHg)
Participants will have the CRT measured over the course of the ICU hospitalization. At the end of the study, multiple linear regression will be performed to verify whether different doses of vasopressor drugs influence CRT value.
Detailed Description
The goal of this observational study is to learn whether different doses of various vasopressor drugs influence capillary refill time (CRT) value in critically ill patients. The main questions it aims to answer are: * How does norepinephrine dose influence CRT value * How does epinephrine dose influence CRT value * How does argipressin dose influence CRT value * How does dobutamine dose influence CRT value * How does mean arterial pressure (MAP) determine CRT value * How often CRT value is normal (\< 3 sec) despite hypotensive MAP (\<65 mmHg) Participants will have the CRT measured over the course of the ICU hospitalization. At the end of the study, multiple linear regression will be performed to verify whether different doses of vasopressor drugs influence CRT value. CRT will be a dependent variable. Independent variables will be as follows: age, MAP, norepinephrine dose, epinephrine dose, argipressin dose, dobutamine dose. CRT measurements will be performed in a standarized rigor (light, chronometer, pressure and ambient temperature will be the same in all patients)
Investigators
Łukasz Krzych
Professor
Medical University of Silesia
Eligibility Criteria
Inclusion Criteria
- •critical illness requiring vasopressor support
- •invasive blood pressure monitoring
Exclusion Criteria
- •finger distal phalanx not available
- •patient in a room of suboptimal ambient temperature
Outcomes
Primary Outcomes
Effect of norepinephrine dose on CRT value
Time Frame: Through study completion, an average of 1 year
In a multiple linear regression, it will be verified whether different doses of norepinephrine determine CRT value.
Effect of mean arterial pressure on CRT value
Time Frame: Through study completion, an average of 1 year
In a multiple linear regression, it will be verified whether different values of MAP determine CRT value.
Secondary Outcomes
- Effect of dobutamine dose on CRT value(Through study completion, an average of 1 year)
- Effect of argipressin dose on CRT value(Through study completion, an average of 1 year)
- CRT value in MAP <65 mmHg(Through study completion, an average of 1 year)
- Effect of epinephrine dose on CRT value(Through study completion, an average of 1 year)