Influence of Vasopressor Support and Mean Arterial Pressure on Capillary Refill Time Values in Critically Ill Patients: Prospective, Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Effect of norepinephrine dose on CRT value
研究概览
简要总结
The goal of this observational study is to learn whether different doses of various vasopressor drugs influence capillary refill time (CRT) value in crtically ill patients. The main questions it aims to answer are:
- How do vasopressor drugs determine CRT value
- How does mean arterial pressure (MAP) determine CRT value
- How often CRT value is normal (< 3 sec) despite hypotensive MAP (<65 mmHg)
Participants will have the CRT measured over the course of the ICU hospitalization. At the end of the study, multiple linear regression will be performed to verify whether different doses of vasopressor drugs influence CRT value.
详细描述
The goal of this observational study is to learn whether different doses of various vasopressor drugs influence capillary refill time (CRT) value in critically ill patients. The main questions it aims to answer are:
- How does norepinephrine dose influence CRT value
- How does epinephrine dose influence CRT value
- How does argipressin dose influence CRT value
- How does dobutamine dose influence CRT value
- How does mean arterial pressure (MAP) determine CRT value
- How often CRT value is normal (< 3 sec) despite hypotensive MAP (<65 mmHg)
Participants will have the CRT measured over the course of the ICU hospitalization. At the end of the study, multiple linear regression will be performed to verify whether different doses of vasopressor drugs influence CRT value. CRT will be a dependent variable. Independent variables will be as follows: age, MAP, norepinephrine dose, epinephrine dose, argipressin dose, dobutamine dose.
CRT measurements will be performed in a standarized rigor (light, chronometer, pressure and ambient temperature will be the same in all patients)
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •critical illness requiring vasopressor support
- •invasive blood pressure monitoring
排除标准
- •finger distal phalanx not available
- •patient in a room of suboptimal ambient temperature
结局指标
主要结局
Effect of norepinephrine dose on CRT value
时间窗: Through study completion, an average of 1 year
In a multiple linear regression, it will be verified whether different doses of norepinephrine determine CRT value.
Effect of mean arterial pressure on CRT value
时间窗: Through study completion, an average of 1 year
In a multiple linear regression, it will be verified whether different values of MAP determine CRT value.
次要结局
- Effect of dobutamine dose on CRT value(Through study completion, an average of 1 year)
- Effect of argipressin dose on CRT value(Through study completion, an average of 1 year)
- CRT value in MAP <65 mmHg(Through study completion, an average of 1 year)
- Effect of epinephrine dose on CRT value(Through study completion, an average of 1 year)
研究者
Łukasz Krzych
Professor
Medical University of Silesia