The Impact of Hybrid-type High-intensity Interval Training on Vitamin D Metabolism in Adults With Overweight/Obesity
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- University of Thessaly
- Enrollment
- 30
- Locations
- 2
- Primary Endpoint
- Change in calcium concentration
Study Overview
Brief Summary
The prevalence of Vitamin D deficiency is significantly higher in adults with overweight/obesity compared to those with normal body mass index (BMI). The "entrapment" of Vitamin D in adipose tissue due to impaired lipolytic stimulation and/or adipose tissue dysfunction has been proposed as the driving mechanism. Exercise training has been proposed as a promising strategy to increase mobilization of Vitamin D from adipose tissue, given its well described role in stimulating lipolysis. Indeed, a recent study revealed that participation in moderate-intensity cardiovascular type exercise over winter can mitigate the decline in 25-hydroxyvitamin D [25(OH)D] in adults with overweight/obesity, independent of weight loss. The aim of this study is to investigate the impact of hybrid-type high-intensity interval training over winter on vitamin D metabolism, in adults with overweight/obesity.
Detailed Description
Thirty adults with overweight/obesity (both males and females) who will meet the inclusion criteria will be randomly assigned to either an Exercise group (n=15) or a Control group (n=15). The Exercise group will participate in three hybrid-type high-intensity interval training sessions per week over a 12-week period, while receiving a balanced diet. The Control group will receive a balanced diet but will not participate in exercise training. Both groups will provide a resting blood sample and undergo assessment of their body composition (via bioelectrical impedance analysis), daily dietary intake (via dietary recalls) and physical activity level (via accelerometry) at baseline (prior to intervention), 6 weeks and 12 weeks.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 35 Years to 50 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •BMI = 25-35 kg/m2
- •Absence of musculoskeletal injuries
- •Absence of chronic health-related complications
- •Non-smokers
Exclusion Criteria
- •Consumption of Vitamin D supplements
- •Consumption of anti-inflammatory drugs, statins and/or steroids
Arms & Interventions
Exercise group
Exercise group will participate in three hybrid-type high-intensity interval training sessions per week over a 12-week period, while receiving a balanced diet
Intervention: Exercise training (Other)
Control group
Control group will receive a balanced diet but will not participate in exercise training
Intervention: Control (Other)
Outcomes
Primary Outcomes
Change in calcium concentration
Time Frame: At baseline, 6 weeks and 12 weeks
Calcium concentration will be determined in serum
Change in albumin concentration
Time Frame: At baseline, 6 weeks and 12 weeks
Albumin concentration will be determined in serum
Change in 25-hydroxyvitamin D concentration
Time Frame: At baseline, 6 weeks and 12 weeks
25-OH-VD will be quantitatively determined in serum
Change in aspartate aminotransferase (SGOT) concentration
Time Frame: At baseline, 6 weeks and 12 weeks
SGOT concentration will be determined in serum on a Clinical Chemistry analyzer
Change in alanine aminotransferase (SGPT) concentration
Time Frame: At baseline, 6 weeks and 12 weeks
SGPT concentration will be determined in serum on a Clinical Chemistry analyzer
Change in plasma Vitamin D binding protein concentration
Time Frame: At baseline, 6 weeks and 12 weeks
Vitamin D binding protein concentration will be determined in plasma
Change in calcium concentration
Time Frame: At baseline, 6 weeks and 12 weeks
Calcium concentration will be determined in serum
Change in albumin concentration
Time Frame: At baseline, 6 weeks and 12 weeks
Albumin concentration will be determined in serum
Change in gamma-glutamyl transferase (γ-GT) concentration
Time Frame: At baseline, 6 weeks and 12 weeks
γ-GT concentration will be determined in serum on a Clinical Chemistry analyzer
Secondary Outcomes
- Change in body composition(At baseline, 6 weeks and 12 weeks)
- Change in dietary intake(At baseline, 6 weeks and 12 weeks)
- Change in physical activity level(At baseline, 6 weeks and 12 weeks)
- Change in oxidized glutathione concentration(At baseline, 6 weeks and 12 weeks)
- Change in body composition(At baseline, 6 weeks and 12 weeks)
- Change in reduced glutathione concentration(At baseline, 6 weeks and 12 weeks)
- Change in physical activity level(At baseline, 6 weeks and 12 weeks)
- Change in dietary intake(At baseline, 6 weeks and 12 weeks)
Investigators
Dimitrios Draganidis
Assistant Professor
University of Thessaly