Correlation of the Inflammatory Parameters With Pain and Radiological Findings in Coxarthrosis

Completed

• Conditions: Pain; Osteoarthritis, Hip; Inflammation
• Interventions: Other: the patients with hip osteoarthritis and their inflammatory status

• Registration Number: NCT04796129
• Lead Sponsor: Istanbul University

Brief Summary

Osteoarthritis (OA) is a functional disease with joint degeneration with subchondral and periosteal lesions. Coxarthrosis (or hip osteoarthritis) is an important cause of disability, especially in the advanced age group.Although hip osteoarthritis is often thought to be a non-inflammatory pathology, recent studies have shown that joint degeneration is correlated with the production of inflammatory factors and cartilage destroying enzymes.

There are very few studies evaluating the correlation of Neutrophil lymphocyte ratio, monocyte lymphocyte ratio and Platelet lymphocyte ratio with inflammatory parameters CRP and ESR levels in hip osteoarthritis and its relation with the staging of hip osteoatritis.

Detailed Description

Osteoarthritis (OA) is a disease characterized by joint degeneration with subchondral and periosteal lesions . Coxarthrosis (hip osteoarthritis) is an important cause of disability, especially in the advanced age group. The risk of symptomatic coxarthrosis in persons up to the age of 85 is approximately 25%. There is a possibility of total hip replacement at a rate of approximately 10% due to advanced stage coxarthrosis. Kellgren-Lawrence staging system is used to show disease severity in osteoarthritis staging. According to this, Stage 0: there is no radiological change, Stage 1: there is a slight narrowing in the joint space, Stage 2: osteophytes are formed in the joint space with stenosis in the anteroposterior radiography, Stage 3: multiple osteophytes, significant narrowing of the joint space, sclerosis and Stage 4 It describes a situation accompanied by large osteophytes, severe stenosis in the joint space, prominent sclerosis, and bone deformities.

Although coxarthrosis is often thought to be a non-inflammatory pathology, recent studies have shown that joint degeneration correlates with the production of inflammatory factors and cartilage destroying enzymes. At the cellular level, it has been found that macrophage and perivascular T and B lymphocyte infiltration play a role in early and advanced stage OA.

Neutrophils and lymphocytes are the main determinants of the inflammatory process. The neutrophil to lymphocyte ratio (NLR) is obtained by dividing the absolute neutrophil count by the number of lymphocytes obtained from the peripheral blood count. They are used as an indicator of the inflammatory process in inflammatory conditions such as ankylosing spondylitis, sarcoidosis, and cancers. In addition, platelet lymphocyte ratio (PLR) has also been found to be associated with disease activity and severity in diseases such as rheumatoid arthritis and psoriatic arthritis. Its use in the diagnosis and follow-up of OA has not yet been clearly demonstrated. However, changes in mean platelet volume are also used as an indicator of disease severity in systemic inflammatory diseases.

There are very few studies evaluating the correlation of Neutrophil lymphocyte ratio, monocyte lymphocyte ratio and Platelet lymphocyte ratio with inflammatory parameters CRP and ESR levels in hip osteoarthritis and its relation with the staging of hip osteoatritis. The aim of this study to evaluate of the correlation of the inflammatory parameters with pain and radiological findings in the patients with coxarthrosis.

Study Timeline

• Study First Submitted: 2021-02-10
• Study Start: 2021-02-11
• Study First Submitted QC: 2021-03-11
• Study First Posted: 2021-03-12
• Primary Completion: 2021-11-10
• Study Completion: 2022-01-10
• Status Verified: 2022-02
• Last Update Submitted: 2022-02-17
• Last Update Posted: 2022-02-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 135

Inclusion Criteria

• Being diagnosed with hip osteoarthritis
• Being aged at 45 years or older

Exclusion Criteria

• Not accept being participation in the study.
• Having any systemic disease like the diabetes mellitus, hypertension, coronary after disease
• Having any inflammatory rheumatologic disease
• Having any disease that prevent to participate the study like mental retardation, dementia and psychotic disorders.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
control	the patients with hip osteoarthritis and their inflammatory status	the participants who have any other comorbidities for impact on the inflammatory status and also no hip pain.
patients with hip osteoarthritis	the patients with hip osteoarthritis and their inflammatory status	the patients who aged 45 and older and have paint in the hips. and also without having any other comorbidities about inflammatory status.

Primary Outcome Measures

Name	Time	Method
NLR	1day	neutrophil lymphocyte ratio
X-ray of hip joints	1 day	an AP X-ray for the painful hip joints
MLR	1 day	monocyte lymphocyte ratio
ESR	1 day	Erythrocyte Sedimentation Ratio
Visual Analog Scale	1 day	pain of the hip joints of the participants. It will be evaluated by using Visual Analog Scale(VAS). The scale is a unidimensional measure of pain intensity, which has been widely used in diverse adult populations. The pain range is from 1 to 10. The minimum value is 1 and it means the pain is so mild. The maximum value is 10, it means the pain is so much, like a knife stabs.
CRP	1 day	C-reactive protein
PLR	1 day	platelet lymphocyte ratio
Lequesne Index	1 day	pain severity

Trial Locations

Locations (1)

Kanuni Sultan Suleyman Training and Research Hospital; 🇹🇷 Istanbul, Turkey