MObILE study - Midodrine effect on Orthostatic IntoLErance after hip and knee replacements
Phase 3
Completed
- Conditions
- Orthostatic IntoleranceTotal Hip arthroplastySurgery - Other surgeryTotal Knee arthroplastyOrthostatic HypotensionCardiovascular - Diseases of the vasculature and circulation including the lymphatic systemNeurological - Other neurological disorders
- Registration Number
- ACTRN12620001342909
- Lead Sponsor
- Waitemata District Health Board
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 170
Inclusion Criteria
18 yr or older
Elective primary unilateral total hip or total knee arthroplasty
Exclusion Criteria
Supine hypertension >180 mmHg preoperatively
Chronic kidney disease (eGFR below 60 mL/min/1.73m2 for more than 3 months)
Hepatic failure
Glaucoma
Chronic urinary retention requiring treatment
Taking doxazosin
Documented recurrent or chronic orthostatic intolerance
Known autonomic nervous system dysfunction
TIA or stroke within the last 12 months
Pregnant
Revision surgery
Unable to walk pre-operatively
Unable to speak or understand English
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method