Quantifying myocardial inflammation in acute rheumatic fever and rheumatic heart disease.

Not Applicable

Recruiting

• Conditions: acute rheumatic fever; rheumatic heart disease; Cardiovascular - Other cardiovascular diseases; Inflammatory and Immune System - Autoimmune diseases; Infection - Other infectious diseases

• Registration Number: ACTRN12621001463864
• Lead Sponsor: Monash University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-10-26
• Last Update Posted: 27 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 185

Inclusion Criteria

ARF group inclusion
-Aged 8 to 35 years
-Definite, probable or possible ARF based on the 2020 Australian criteria for ARF diagnosis

Non-ARF inflammatory group inclusion
-Aged 8 to 35 years
-Acute inflammatory/infective condition

Control group inclusion
-Aged 8 to 35 years
- Currently well/healthy

Exclusion Criteria

ARF group exclusion criteria
-Claustrophobia
-Metal implant/object that precludes cardiac MRI
-Pregnant or breastfeeding women

Non-ARF inflammatory group exclusion criteria
-Probable ARF
-Any major criteria for ARF
-Chest pain
-Signs/symptoms of heart failure
-History of ARF/RHD
-More than mild valvular disease on echocardiogram
-Inflammatory condition commonly caused by streptococcal in which no alternate organism has been identified
-Known recent/current streptococcal infection (within 6 months of enrolment)
-Claustrophobia
-Metal implant/object that precludes cardiac MRI
-Pregnant or breastfeeding women

Control group exclusion
-Any infective or inflammatory condition
-History of ARF/RHD
-More than mild valvular disease on echocardiogram
-Known streptococcal infection within 6 months of enrolment
-Any major or minor criteria for ARF
-Chest pain
-Signs or symptoms of heart failure
-Claustrophobia
-Metal implant/object that precludes cardiac MRI
-Pregnant or breastfeeding women

Study & Design

• Study Type: Observational
• Study Design: Not specified