Cerebral energy homeostasis upon lactate infusio
Phase 4
- Conditions
- healthy subjects
- Registration Number
- DRKS00014563
- Lead Sponsor
- Sektion für Psychoneurobiologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 16
Inclusion Criteria
normal weight, 20-30 years
Exclusion Criteria
diabetes mellitus, overweight (BMI > 26 kg/m²), chronic or acute illness, alcohol or drug abuse, smoking, competitive physical exercise, exceptional physical or mental stress, current medication of any kind
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method measurement of cerebral high-energy phosphates (adenosine triphosphate (ATP), phosphocreatine (PCr), inorganic phosphate (Pi)) by 31P-magnetic resonance spectroskopy (3.0 Tesla MR scanner) on six time points of measurement (Baseline, 15 minutes after start of lactate or placebo infusion, 3 measurements during hypoglycemia (every 20 minutes), 1 measurement after hypoglycemia)
- Secondary Outcome Measures
Name Time Method counterregulatory hormones (ACTH, cortisol, epinephrine, norepinephrine) by analyses of blood samples on 10 time points of measurement (Baseline, after 60 minutes, 15 minutes after start of lactate or placebo infusion, 6 blood samples during hypoglycemia (every 10 minutes), 1 blood sample after hypoglycemia)