Aerobic Exercise for Smokers With Depressive Symptomatology
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 231
- 试验地点
- 2
- 主要终点
- Smoking Cessation
研究概览
简要总结
The purpose of this study is to test the effect of a moderate-intensity aerobic exercise intervention for helping individuals with elevated depressive symptoms to quit smoking. The investigators expect that this project will contribute much needed knowledge about the role that aerobic exercise can play in smoking cessation. The long-term goal of this program of research is to disseminate an effective, aerobic exercise (AE) intervention for smoking cessation that can be readily adopted by smokers with elevated depressive symptoms, including those with current major depressive disorder (MDD).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •are between 18 and 65 years of age
- •are current smokers (i.e., smoking at least 10 cigarettes per day)
- •have currently elevated depressive symptoms (CES-D ≥ 6)
- •are sedentary, i.e., have not participated regularly in aerobic exercise (for at least 90 minutes per week during the past three months)
排除标准
- •DSM-IV diagnosis of current mania
- •DSM-IV diagnosis of bipolar rapid cycling
- •lifetime history of psychotic disorder or DSM-IV diagnosis of current psychotic symptoms
- •DSM-IV diagnosis of current substance abuse or dependence in the past 6 months
- •DSM-IV diagnosis of anorexia or bulimia nervosa
- •current suicidality or homicidality
- •marked organic impairment
- •current use of antidepressant medication for less than 3 months or change in antidepressant medication or dosage in the past 3 months,
- •physical disabilities or medical problems that would prevent or hinder participation in a program of moderate intensity exercise (i.e., physician denied medical clearance)
- •current pregnancy or intent to become pregnant during the next 12 weeks
- •contraindications for use of the nicotine patch (e.g., pregnancy, recent myocardial infarction, arrhythmia, angina, untreated hypertension, untreated diabetes, and previous adverse reaction to the patch)
- •current illness or medications that may alter proposed inflammatory markers (e.g., acute infection, immune disorders, aspirin)
- •current use of any pharmacotherapy or other treatment for smoking cessation.
研究组 & 干预措施
Exercise
12-week moderate-intensity behavioral exercise intervention (AE)
干预措施: Aerobic Exercise (Behavioral)
Health Education
12-week health education control
干预措施: Health Education (Behavioral)
结局指标
主要结局
Smoking Cessation
时间窗: 1 year
Abstinence from smoking verified biochemically (saliva cotinine)
次要结局
未报告次要终点