Is The Combine Prolotherapy More Effective Than The Traditional Prolotherapy In Patients With Temporomandibular Joint Hypermobility?
Overview
- Phase
- Phase 4
- Status
- Completed
- Enrollment
- 26
- Locations
- 1
- Primary Endpoint
- Pain intensity of TMJ
Overview
Brief Summary
- Diagnosis and Indication You have been diagnosed with temporomandibular joint (TMJ) hypermobility and/or dysfunction, characterized by symptoms such as jaw clicking, locking, pain in the joint area, or difficulty in opening and closing the mouth. After clinical and radiographic evaluation, the recommended treatment includes arthrocentesis and prolotherapy, either alone or in combination.
- Description of Procedures
A. TMJ Arthrocentesis:
This is a minimally invasive procedure in which small needles are inserted into the TMJ space to irrigate the joint using sterile fluid (e.g., Ringer's solution). The procedure aims to eliminate inflammatory mediators, release joint adhesions, and improve mandibular mobility. It is generally performed under local anesthesia in an outpatient setting.
B. Prolotherapy:
Prolotherapy involves the injection of an irritant solution (typically dextrose combined with a local anesthetic) into the joint capsule, ligaments, or surrounding tissue. The goal is to stimulate the body's natural healing response, promoting collagen production and tissue regeneration to improve joint stability and function.
C. Combined Approach:
In certain cases, both treatments may be performed during the same session to maximize clinical benefit-arthrocentesis addresses inflammation and mobility, while prolotherapy enhances long-term stabilization. 3. Benefits and Expected Outcomes Reduction in TMJ pain and joint clicking
Improved jaw function and range of motion
Stabilization of the joint and reduced recurrence of dislocation or subluxation
Minimally invasive and generally well-tolerated 4. Possible Risks and Complications
Although these procedures are generally safe, potential risks may include but are not limited to:
Mild pain or swelling at the injection site
Temporary facial numbness or weakness (rare and usually self-resolving)
Dizziness or light-headedness
Joint stiffness or infection (very rare)
Allergic reaction to anesthetic or injected substances 5. Alternatives to the Proposed Procedure
You have the right to consider other treatment options, which may include:
Physical therapy or jaw exercises
Oral splints or bite guards
Medication (analgesics, muscle relaxants)
Surgical interventions (if conservative methods fail) 6. Patient Instructions and Post-Procedure Care Avoid wide mouth opening, yawning, or chewing hard foods for several days
Use only recommended medications (e.g., acetaminophen/paracetamol); avoid anti-inflammatory drugs unless advised otherwise
Apply cold compresses to reduce swelling if necessary
Attend all scheduled follow-up appointments
Notify your doctor immediately if you experience severe pain, prolonged numbness, fever, or signs of infection
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 17 Years to 46 Years (Child, Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patients with unilateral or bilateral TMJ hypermobility
- •history of open locking
- •complaints of joint sounds and facial pain
- •treated with combine or traditionally prolotherapy
- •followed for at least 3 months
- •the diagnosis of the patients was confirmed by TMJ radiography
Exclusion Criteria
- •patients who underwent discectomy
- •patients with active infection (fever, redness, oedema, loss of function, etc.)
- •pathological findings (tumour, cyst, etc.) in the related area were excluded
- •patients with systemic disorders that could affect the results
Arms & Interventions
Combined Prolotherapy Group
Patients with TMJ hypermobility underwent arthrocentesis for joint pain in addition to prolotherapy.
Intervention: prolotherapy solution of 20% dextrose (Drug)
Combined Prolotherapy Group
Patients with TMJ hypermobility underwent arthrocentesis for joint pain in addition to prolotherapy.
Intervention: Arthrocentesis with ringer solution (Drug)
Traditional Prolotherapy Group
Prolotherapy was applied to patients with TMJ hypermobility.
Intervention: prolotherapy solution of 20% dextrose (Drug)
Outcomes
Primary Outcomes
Pain intensity of TMJ
Time Frame: From pre-treatment to the 3rd month after treatment
Pain intensity of TMJ evaluated by visual analog scale (VAS) questionnaire. VAS is designated by an marked horizontal line, 10 mm long, scored from 0 (no pain) to 10 (intolerable pain), anchored by word identifiers at each end. Patients marked the point on the line that they thought represented their current situation.
Secondary Outcomes
- Maximal interincisal opening (MIO)(From pre-treatment to the 3rd month after treatment)
Investigators
Halenur Ateş
DDS
Karadeniz Technical University